[Todos] Recordatorio -Seminarios conjuntos IFIBYNE-DFBMC viernes 15-11 13 Hs.Dr. Francesc Posas

[Paula Felman]

Viernes 15 de noviembre 13 hs. en el aula de seminarios



Coordinated control of gene expression and cell 
cycle progression by stress-activated protein kinases (SAPKs).

Cell Signaling Unit, Departament de Ciències 
Experimentals i de la Salut. Universitat Pompeu 
Fabra (UPF). PRBB. C/ Doctor Aiguader 88. 
Barcelona E-08003 (Spain). 
<mailto:francesc.posas en upf.edu>francesc.posas en upf.edu


Exposure of cells to increases in extracellular 
osmolarity results in the activation of the 
Hog1/p38 family of stress-activated protein 
kinases (SAPKs). Activation of these SAPKs is 
required to generate a set of osmoadaptive 
responses essential to survive under high 
osmolarity highly conserved among eukaryotic 
cells. Osmostress induces a large number of 
genes, which indicates the necessity to regulate 
several aspects of the cell physiology for proper 
cellular adaptation. In yeast, the Hog1 SAPK 
controls several steps in mRNA biogenesis from 
transcription initiation to mRNA export and 
translation. In response to stress, the SAPK also 
modulates cell cycle progression. Both in yeast 
and mammals, p38/Hog1 control cell cycle by 
delaying different phases of cell cycle by acting 
on several components of the cell cycle core 
machinery. In fact, the processes of 
transcription and cell cycle are strongly 
coordinated to maximize cell survival upon stress.



Alejandro Colman-Lerner
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