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Viernes 15 de noviembre 13 hs. en el aula de seminarios<br><br>
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<b>Coordinated control of gene expression and cell cycle progression by
stress-activated protein kinases (SAPKs). <br>
</b> <br>
<i>Cell Signaling Unit, Departament de Ciències Experimentals i de la
Salut. Universitat Pompeu Fabra (UPF). </i>PRBB.<i> C/ Doctor Aiguader
88. Barcelona E-08003 (Spain).
<a href="mailto:francesc.posas@upf.edu">francesc.posas@upf.edu</a><br>
</i> <br>
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Exposure of cells to increases in extracellular osmolarity results in the
activation of the Hog1/p38 family of stress-activated protein kinases
(SAPKs). Activation of these SAPKs is required to generate a set of
osmoadaptive responses essential to survive under high osmolarity highly
conserved among eukaryotic cells. Osmostress induces a large number of
genes, which indicates the necessity to regulate several aspects of the
cell physiology for proper cellular adaptation. In yeast, the Hog1 SAPK
controls several steps in mRNA biogenesis from transcription initiation
to mRNA export and translation. In response to stress, the SAPK also
modulates cell cycle progression. Both in yeast and mammals, p38/Hog1
control cell cycle by delaying different phases of cell cycle by acting
on several components of the cell cycle core machinery. In fact, the
processes of transcription and cell cycle are strongly coordinated to
maximize cell survival upon stress. <br>
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<br><br>
Alejandro Colman-Lerner <br>
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