[Todos] Seminarios conjuntos DFBMC-IFIByNE- Rafael Pagani (RECORDATORIO)

[LFBM - FCEyN - UBA]

Seminario jueves 12 de marzo, 13 hs. Aula de seminarios del LFBM

Rafael Pagani



Gain-of-Function Mutations Causing Noonan Syndrome Modulate the 
Inter-trial Interval required for Long-term Memory Induction in Drosophila


SUMMARY
Noonan syndrome (NS) is a genetic disorder comprising a range of 
developmental and cognitive abnormalities. The major cause is 
gain-of-function (GOF) mutations in PTPN11, which encodes the 
tyrosine phosphatase SHP-2. To gain insights into these cognitive 
alterations, we used transgenic Drosophila NS models inducibly 
expressing the fly SHP-2 orthologue, corkscrew (CSW). Our studies 
revealed that GOF CSW impairs long-term memory (LTM) formation even 
when acutely expressed in adulthood. A universal property of LTM 
induction is the requirement for repeated training sessions spaced 
over time. The molecular basis of this spacing effect is completely 
unknown. We demonstrated that wild-type CSW overexpression 
dramatically shortened the interval between training sessions 
required for LTM induction. Conversely, the LTM formation defect in 
the NS fly models could be rescued by increasing the inter-trial 
interval. Thus, we provide the first evidence that the spacing effect 
has a molecular base and CSW/SHP-2 is key in its regulation.

Host: Alejandro Colman Lerner
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