[Todos] Seminario IFIBYNE - DFBMC 9 de septiembre 13 hs. Alberto Kornblihtt

[Paula Felman]

Jueves 9 de septiembre 13 Hs.

 Aula de seminarios del LFBM

>Expositor: Alberto Kornblihtt.
>Título: Organogénesis interespecífica
>
>Seminario sobre el paper recientemente publicado:
>
>
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>Generation of Rat Pancreas in Mouse by 
>Interspecific Blastocyst Injection of Pluripotent Stem Cells
>
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>Toshihiro Kobayashi,Tomoyuki Yamaguchi,Sanae 
>Hamanaka,Megumi Kato-Itoh,Yuji Yamazaki,Makoto 
>Ibata,Hideyuki Sato,Youn-Su Lee,Jo-ichi 
>Usui,A.S. Knisely,Masumi Hirabayashi,Hiromitsu Nakauchi
>
>
>
>Interspecies Organogenesis
>The goal of regenerative medicine is to derive 
>organs from patient’s pluripotent stem cells. In 
>a tour-de-force study, by injecting rat PSCs 
>into mouse blastocytes, Nakauchi and colleagues 
>generate a functioning rat pancreas in mice 
>deficient for a pancreas; in the process, the 
>authors also describe the first viable rat-mouse chimeras.
>
>Summary.
>The complexity of organogenesis hinders in vitro 
>generation of organs derived from a patient's 
>pluripotent stem cells (PSCs), an ultimate goal 
>of regenerative medicine. Mouse wild-type PSCs 
>injected into Pdx1 / (pancreatogenesis-disabled) 
>mouse blastocysts developmentally compensated 
>vacancy of the pancreatic “developmental niche,” 
>generating almost entirely PSC-derived pancreas. 
>To examine the potential for xenogenic 
>approaches in blastocyst complementation, we 
>injected mouse or rat PSCs into rat or mouse 
>blastocysts, respectively, generating 
>interspecific chimeras and thus confirming that 
>PSCs can contribute to xenogenic development 
>between mouse and rat. The development of these 
>mouse/rat chimeras was primarily influenced by 
>host blastocyst and/or foster mother, evident by 
>body size and species-specific organogenesis. We 
>further injected rat wild-type PSCs into Pdx1 
>/  mouse blastocysts, generating normally 
>functioning rat pancreas in Pdx1 /  mice. These 
>data constitute proof of principle for 
>interspecific blastocyst complementation and for 
>generation in vivo of organs derived from donor 
>PSCs using a xenogenic environment.
>
>--
>Alejandro Colman-Lerner
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