[Todos] SEMINARIO HOY

[Fernando V. Molina]

Lunes 27 de agosto - 13 hs

Aula de Seminarios INQUIMAE-DQIAQF (3º piso Pab. II)


Prof. Henry S. White
Department of Chemistry, University of Utah
315 S 1400 E, Salt Lake City, Utah, 84112 U.S.A.


"ELECTROCHEMISTRY IN SYNTHETIC AND BIOLOGICAL NANOPORES"


Abstract:
Advances in molecular biology and analytical 
chemistry have led to a new class of sensors 
based on electrochemical and electrical 
measurements of molecular fluxes and ion 
conductances in pores of nanometer dimensions. In 
this presentation, the fabrication of biochemical 
sensors based on “glass nanopore electrodes” and 
“glass nanopore membranes”, will be described.
These structures are fabricated from glass and 
quartz, and contain a single conical shaped pore 
with orifice radius between 5 and 500 nm. A 
consequence of the conical shape is that the 
observable ion conductance (or redox molecule 
flux) largely reflects the magnitude of the 
solution resistance in the immediate vicinity of 
the pore orifice. This property makes the 
electrical response of the glass nanopores very 
sensitive to small numbers of chemical 
interactions between analyte molecules and the 
orifice surface. Glass nanopore electrodes and 
membranes with orifice radii as small as 5 nm 
have been chemically modified by: covalent 
attachment of receptor molecules to the glass 
surfaces; by filling the pore volume with 
polymers and hydrogels; and by deposition of 
lipid bilayers across the pore orifice. These 
chemical modifications impart selectivity and 
sensitivity (single molecule and single particle 
detection) for a diverse range of applications, 
including use as solid supports for protein ion 
channel recordings resistive pulse counting of 
particles with diameters as small as 10 nm; 
sensors for a variety of environmental stimuli 
(e.g., photons, pH); and use as a structural 
support for ion selective electrodes upon filling 
the pore with reference electrodes and permselective membranes.


Henry S. White
Activities & Awards
Grahame Award of the Electrochemical Society, 2005
ACS Analytical Division Award in Electrochemistry, 2004
University of Utah, Distinguished Research Award, 2004
Faraday Medal, Royal Society of Chemistry, London, 2002
Reilley Award of the Society of Electroanalytical Chemistry, 2000
Shell Chair of Chemical Engineering and Materials Science, University of
Minnesota, 1992
Associate Editor, Journal of the American Chemical Society
President, Society of Electroanalytical Chemistry, 2003-05
------------ próxima parte ------------
Se ha borrado un adjunto en formato HTML...
URL: http://mail.df.uba.ar/pipermail/todos/attachments/20070827/bf1df840/attachment.html