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<br>
<div align="center"><font size=5><b>Lunes 27 de agosto - 13 hs<br><br>
</b>Aula de Seminarios INQUIMAE-DQIAQF (3º piso Pab. II) <br><br>
<br>
</font><font size=6><b>Prof. Henry S. White <br>
</font><font size=4><i>Department of Chemistry, University of
Utah</i></font><font size=6> <br>
</font><font size=4><i>315 S 1400 E, Salt Lake City, Utah, 84112
U.S.A.<br><br>
<br>
</i></font><font size=5>"ELECTROCHEMISTRY IN SYNTHETIC AND
BIOLOGICAL NANOPORES"<br><br>
<br>
</b></font></div>
Abstract:<br>
Advances in molecular biology and analytical chemistry have led to a new
class of sensors based on electrochemical and electrical measurements of
molecular fluxes and ion conductances in pores of nanometer dimensions.
In this presentation, the fabrication of biochemical sensors based on
“glass nanopore electrodes” and “glass nanopore membranes”, will be
described.<br>
These structures are fabricated from glass and quartz, and contain a
single conical shaped pore with orifice radius between 5 and 500 nm. A
consequence of the conical shape is that the observable ion conductance
(or redox molecule flux) largely reflects the magnitude of the solution
resistance in the immediate vicinity of the pore orifice. This property
makes the electrical response of the glass nanopores very sensitive to
small numbers of chemical interactions between analyte molecules and the
orifice surface. Glass nanopore electrodes and membranes with orifice
radii as small as 5 nm have been chemically modified by: covalent
attachment of receptor molecules to the glass surfaces; by filling the
pore volume with polymers and hydrogels; and by deposition of lipid
bilayers across the pore orifice. These chemical modifications impart
selectivity and sensitivity (single molecule and single particle
detection) for a diverse range of applications, including use as solid
supports for protein ion channel recordings resistive pulse counting of
particles with diameters as small as 10 nm; sensors for a variety of
environmental stimuli (e.g., photons, pH); and use as a structural
support for ion selective electrodes upon filling the pore with reference
electrodes and permselective membranes.<br><br>
<br>
Henry S. White<br>
Activities & Awards<br>
Grahame Award of the Electrochemical Society, 2005<br>
ACS Analytical Division Award in Electrochemistry, 2004<br>
University of Utah, Distinguished Research Award, 2004<br>
Faraday Medal, Royal Society of Chemistry, London, 2002<br>
Reilley Award of the Society of Electroanalytical Chemistry, 2000<br>
Shell Chair of Chemical Engineering and Materials Science, University
of<br>
Minnesota, 1992<br>
Associate Editor, Journal of the American Chemical Society<br>
President, Society of Electroanalytical Chemistry, 2003-05<br>
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