[Todos] Fw: favor difundir, gracias

Fernando D Marengo fernando en fbmc.fcen.uba.ar
Jue Mar 30 11:18:07 ART 2006 

FW: favor difundir, graciasreenvío el anuncio de un interesante seminario en fund. leloir
Fernando
----- Original Message ----- 
From: Graciela Lidia Boccaccio 
To: fernando en fbmc.fcen.uba.ar 
Sent: Thursday, March 30, 2006 9:44 AM
Subject: FW: favor difundir, gracias





Estimados, 
les adjunto anuncio del seminario de David Colman en la FIL. 
Esta presentación será distinta de la conferencia plenaria que tendrá lugar en el taller de neurociencias, enfocada en otra de sus muy creativas líneas de investigación. Dave es un orador ameno, para no perderse una de sus escasas visitas a Arg.

El seminario es puntualmente 13:30 hs, en el auditorio de planta baja. Habrá café en el hall después de la conferencia. 

gracias y saludos, graciela 

--------------------------------------------------------------------------- 
Jueves 6 de Abril, 13:30 hs 
Fundación Instituto Leloir  (Auditorio) 



"Cellular adhesion mechanisms in the formation of the myelin sheath" 

David R Colman 

Penfield Professor and Director, 

The Montreal Neurological Institute 

of McGill University, Montreal, Canada 
<http://www.mni.mcgill.ca/cbet.html> 




Research in Dr. David Colman's laboratory deals primarily with the interactions between cell adhesion molecules. One model we use is the vertebrate myelin sheath, which is a broad, flattened, self-adherent membrane that surrounds axons and allows for the rapid conduction of the nerve impulse. The sheath is an excellent model for studying fundamental questions about plasma membrane biogenesis in the nervous system. How the almost crystalline ultrastructure of the myelin sheath is assembled is a fascinating problem, and the examination of the molecular interactions by which the sheath is formed is a major focus of the laboratory. Studies on the biochemistry, molecular structure and most recently the evolutionary origins of the myelin proteins are providing intriguing insights into their general properties and their actual roles in the formation and maintenance of the sheath.

In other studies, we are focusing on the adhesion mechanisms by which intercellular junctions, and in particular the pre- and post-synaptic membranes in the CNS, are held together. We have found that cadherins, calcium dependent adhesion molecules that operate in all epithelial cells, are important components of the CNS synaptic junctions. In fact, it is possible that the differential adhesive specificities of individual cadherins may be responsible in large measure for the high degree of specificity of synaptic connections in the CNS. 



  Selected publications (from a total of 102):

  Shan, W.S., Yoshida, M., Colman, D.R., and Shapiro, L.  2000.  Functional cis-heterodimers of N- and R-cadherins.  J. Cell Biol. 148:579-590.

  Zalc, B., and Colman, D.R.  2000.  Origins of vertebrate success.  Science 288:271-272. 

Tait S., Gunn-Moore F., Collinson J.M., Huang J., Lubetzki C., Pedraza L., Sherman D.L., Colman D.R., and Brophy P.J.  2000.  An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction. J Cell Biol. 150:657-66.

  Phillips, G., Huang, J.,Wang, Y., Gordon, R.E., Tanaka, H., Shan, W-S., Arndt, K., Shapiro, L., Zhao, Y-M., and Colman, D.R.  2001.  The presynaptic particle web:ultrastructure, composition, dissolution and reconstitution. Neuron, 32: 63-77.

  Pedraza, L., Huang, J.K., and Colman, D.R.  2001.  Organizing principles of the axoglial apparatus. Neuron, 30:335-344. 
  Benson, D.L., Colman, D.R., and Huntley, G.W.  2001  Molecules, maps and synapse specificity. Nature Reviews Neuroscience, 2:899-909.

  Colman, D.R. and Dustin, M.  2002.  The neural and the immune synapse. (Science, 298:785-789). 
  Huntley, G.W., Benson, D.L., and Colman, D.R.  2002.  Structural remodeling of the synapse in response to physiological activity. Cell 108:1-4.

  Phillips, G.R., Tanaka, H., Frank, M. Elste, A., Fidler, L., Benson, D.L., and Colman,              D.R.  2003.  γ-Protocadherins are targeted to subsets of synapses and intracellular organelles in neurons. J. Neurosci. 23: 5096-5104.

  Colman D., Lubetzki, C., and Reingold, S.  2003.  Multiple paths towards repair in multiple sclerosis. Trends Neurosci 26(2):59-61.

  Colman, D.R.  2004.  Obedient and wayward synaptic behavior. Cell 116(6):869-81. 

  Koch, A.W., Farooq, A., Shan, W., Zeng L., Colman, D. R., and Zhou, M. M.  2004.  Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics. Structure 12(5):793-805.

  Phillips, G.R., Anderson, T.R., Florens, L., Gudas, C., Magda, G., Yater, J.R. 3rd, and Colman, D.R.  2004.  Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines. J Neurosci Res 78:38-45.

  Okamura, K., Tanaka, H., Yagita, Y., Saeki, Y., Hiraoka, Y., Zeng, L.H., Colman, D. R. and Miki, N.  2004.  Cadherin activity is required for activity induced spine remodeling. J. Cell Biology 167:961-72. 

  Shan, W, Yagita Y, Wang Z, Koch A, Svenningsen AF, Gruzglin E, Pedraza L, Colman DR.  2004. The minimal essential unit for cadherin-mediated intercellular adhesion comprises extracellular domains 1 and 2. J Biol Chem. 279:55914-23. 

  Frank, M., Ebert, M., Shan, W., Phillips, G.R., Arndt, K., Colman, D.R., and Kemler, R. 2005. Differential expression of individual gamma-protocadherins during mouse brain development.  Mol. Cell Neurosci. 29:603-16.

  Huang, JK., Phillips, G., Roth, AD., Pedraza, L., Shan, W., Belkaid, W., Sha, M., Fex-Sveningsen, A., Florens, L., Yates, JR., and Colman, DR. 2005. Glial membranes at the node of Ranvier prevent neurite outgrowth. Science 310:1813-1817. 

Shapiro, L., Love, J., and Colman, DR. 2006. Adhesion molecules in the nervous system: structural basis of function and diversity. Ann. Rev. Neurosci. 29 (in press)




Graciela L. Boccaccio Ph.D. 
Myelin Cell Biology Laboratory 
Fundación Instituto Leloir 
TEL: 54 11 5238 7500 ext 3108 
Fax: 54 11 5238 7501 
E-mail: gboccaccio en leloir.org.ar <mailto:gboccaccio en leloir.org.ar> 
  
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