<html><head><meta http-equiv="Content-Type" content="text/html charset=iso-8859-1"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div><br></div><br><div><span style="font-size: 14px;">SEMINARIO EN EL </span><span style="font-size: 14px; font-family: arial, sans-serif;">DEPARTAMENTO DE FÍSICA FCEYN - UBA</span><br><font color="#0f61c8" face="arial, sans-serif"><span style="font-size: 14px;"><br></span></font><font face="arial, sans-serif" style="font-size: 14px;"><span class="Apple-tab-span" style="white-space:pre"> </span></font><span style="font-size: 14px; font-family: arial, sans-serif;">En el </span><span style="font-size: 14px;">Aula Seminario, 2do piso, Pabellón I</span><span style="font-size: 14px; font-family: arial, sans-serif;">,</span><br><font color="#0f61c8" face="arial, sans-serif"><span style="font-size: 14px;"><br></span></font><span class="Apple-tab-span" style="font-size: 14px; font-family: arial, sans-serif; white-space: pre;"> </span><span style="font-size: 14px; font-family: arial, sans-serif;">Lunes 29 / 9, 15hs:</span><br><font color="#0f61c8" face="arial, sans-serif"><span style="font-size: 14px;"><br></span></font><span class="Apple-tab-span" style="font-size: 14px; font-family: arial, sans-serif; white-space: pre;"> </span><span style="font-size: 14px; font-family: arial, sans-serif;">ENRICO GRATTON</span><br><font color="#0f61c8" face="arial, sans-serif"><span style="font-size: 14px;"><br></span></font><font face="arial, sans-serif" style="font-size: 14px;"><span class="Apple-tab-span" style="white-space:pre"> </span></font><span style="font-size: 14px; font-family: Arial;">Laboratory for Fluorescence Dynamics, University of California, Irvine.</span><br><font color="#0f61c8" face="Arial"><span style="font-size: 14px;"><br></span></font><b style="font-family: Arial; font-size: 14px;"><span class="Apple-tab-span" style="white-space: pre;"> </span>Super-resolution by feedback imaging: </b><br><b style="font-family: Arial; font-size: 14px;"><span class="Apple-tab-span" style="white-space:pre"> </span>Mechanisms of translocation through the nuclear pore complex</b><br><font color="#0f61c8"><span style="font-size: 14px;"><br></span></font><span style="font-family: Arial; font-size: small;">In a eukaryotic cell, all traffic between the nucleus and the cytoplasm is regulated by the nuclear pore complex. Much is known about the structure of the nuclear pore complex. However, the mechanism that allows very large particle to pass through the pore is still debated. In this presentation I will discuss current models proposed for the opening and closing of the pore. I will present recent experimental evidence from my lab which poses strong constrains about possible mechanisms. I will describe a nanoimaging technique that has a very high time and spatial resolution. This techniques is based on the observation of single molecules using feedback imaging. Using this technique we can observe the translocation of particles in great detail and reveal possible mechanisms of action of the nuclear pore complex.</span><br></div><div><span style="font-family: Arial; font-size: small;"><br></span></div><div><span style="font-family: Arial; font-size: small;"><br></span></div><br></body></html>