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<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;line-height:
normal'><b><span style='font-size:14.0pt;font-family:"Times New Roman","serif"'>SEMINARIO
DE QUIMICA ORGANICA 2011<o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;line-height:
normal'><b><span style='font-size:16.0pt;font-family:"Times New Roman","serif";
color:#00B050'>Viernes 11 de noviembre, 11 hs<o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;line-height:
normal'><b><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Aula
de Seminario, Departamento de Química Orgánica, FCEyN<o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal'><b><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></b></p>
<p class=MsoNormal align=center style='margin-bottom:0cm;margin-bottom:.0001pt;
text-align:center;line-height:normal'><b><span lang=EN-US style='font-size:
16.0pt;font-family:"Times New Roman","serif";color:#002060'> Prof. C. Oliver
Kappe<o:p></o:p></span></b></p>
<p class=MsoNormal align=center style='margin-bottom:0cm;margin-bottom:.0001pt;
text-align:center;line-height:normal'><b><span lang=EN-US style='font-size:
16.0pt;font-family:"Times New Roman","serif";color:#002060'><o:p> </o:p></span></b></p>
<p class=MsoNormal align=center style='margin-bottom:0cm;margin-bottom:.0001pt;
text-align:center;line-height:normal'><b><span lang=EN-US style='font-size:
12.0pt;font-family:"Times New Roman","serif";color:#002060'>Christian Doppler
Laboratory for Microwave Chemistry and Institute of Chemistry,<o:p></o:p></span></b></p>
<p class=MsoNormal align=center style='margin-bottom:0cm;margin-bottom:.0001pt;
text-align:center;line-height:normal'><b><span lang=EN-US style='font-size:
12.0pt;font-family:"Times New Roman","serif";color:#002060'> Karl-Franzens-University
Graz, A-8010 Graz, Austria<o:p></o:p></span></b></p>
<p class=MsoNormal align=center style='margin-bottom:0cm;margin-bottom:.0001pt;
text-align:center;line-height:normal'><b><span lang=EN-US style='font-size:
12.0pt;font-family:"Times New Roman","serif";color:#002060'>oliver.kappe@uni-graz.at
/ www.maos.net<o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal'><span lang=EN-US style='font-size:12.0pt;
font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal align=center style='margin-bottom:0cm;margin-bottom:.0001pt;
text-align:center;line-height:normal'><b><span lang=EN-US style='font-size:
18.0pt;font-family:"Times New Roman","serif";color:#C00000'>Microwave-assisted
organic synthesis. From laboratory curiosity to standard practice in 25 years <o:p></o:p></span></b></p>
<p class=MsoNormal align=center style='margin-bottom:0cm;margin-bottom:.0001pt;
text-align:center;line-height:normal'><b><span lang=EN-US style='font-size:
16.0pt;font-family:"Times New Roman","serif";color:#C00000'><o:p> </o:p></span></b></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal'><span lang=EN-US style='font-size:12.0pt;
font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal style='text-align:justify;text-indent:35.4pt'><span
lang=EN-US style='font-family:"Times New Roman","serif"'>High-speed microwave
synthesis has attracted a considerable amount of attention in recent years
[1-3]. Since the first reports on the use of microwave heating to accelerate
organic chemical transformations by the groups of Gedye and Giguere/Majetich in
1986, more than 3000 articles have been published in the area of microwave-assisted
organic synthesis (MAOS) [2]. The initial slow uptake of the technology in the
late 1980s and early 1990s has been attributed to its lack of controllability
and reproducibility, coupled with a general lack of understanding of the basics
of microwave dielectric heating. The risks associated with the flammability of
organic solvents in a microwave field and the lack of available systems for
adequate temperature and pressure controls were major concerns. Since the late
1990s the number of publications related to MAOS has therefore increased
dramatically to a point where it might be assumed that, in a few years, most
chemists will probably use microwave energy to heat chemical reactions on a
laboratory scale. Not only is direct microwave heating able to reduce chemical
reaction times from hours to minutes, but it is also known to reduce side
reactions, increase yields and improve reproducibility. Therefore, many
academic and industrial research groups are already using MAOS as a forefront
technology for rapid reaction optimization, for the efficient synthesis of new
chemical entities, or for discovering and probing new chemical reactivity. <o:p></o:p></span></p>
<p class=MsoNormal style='text-align:justify;text-indent:35.4pt'><span
lang=EN-US style='font-family:"Times New Roman","serif"'>This lecture will
highlight contributions from our laboratory in the field of microwave-assisted
organic synthesis, in particular as they relate to heterocyclic synthesis,
combinatorial chemistry and the question of scale-up of microwave-assisted
reactions.<o:p></o:p></span></p>
<p class=MsoNormal style='text-align:justify'><span lang=EN-US
style='font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal style='text-align:justify'><span lang=EN-US
style='font-family:"Times New Roman","serif"'>References<o:p></o:p></span></p>
<p class=MsoNormal style='text-align:justify;text-indent:35.4pt'><span
lang=EN-US style='font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:18.0pt;text-indent:-18.0pt'><span
lang=EN-US style='font-family:"Times New Roman","serif"'>[1] Kappe, C. O.
“Controlled microwave heating in modern organic synthesis.” </span><i><span
lang=EN-GB style='font-family:"Times New Roman","serif"'>Angew. Chem. Int. Ed.</span></i><span
lang=EN-GB style='font-family:"Times New Roman","serif"'> <b>2004</b>, <i>43</i>,
6250.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:18.0pt;text-indent:-18.0pt'><span
lang=EN-GB style='font-family:"Times New Roman","serif"'>[2] Kappe, C. O.;
Stadler, A. "Microwaves in organic and medicinal chemistry",
Wiley-VCH, <b>2005</b>.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:18.0pt;text-indent:-18.0pt'><span
lang=EN-GB style='font-family:"Times New Roman","serif"'>[3] Kappe, C. O.;
Dallinger, D.; Murphree, “Practical Microwave Synthesis for Organic Chemists”,
Wiley-VCH,<i> </i><b>2009</b>.<o:p></o:p></span></p>
<p class=MsoNormal style='text-align:justify'><span lang=EN-GB><o:p> </o:p></span></p>
<h1 align=center style='text-align:center'><span lang=EN-US><o:p> </o:p></span></h1>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
<h1><span lang=EN-US>Professor C. Oliver Kappe<o:p></o:p></span></h1>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
<p class=intro style='margin-left:7.5pt;text-align:justify'><span lang=EN-US
style='font-size:11.0pt'>C. Oliver Kappe is Professor of Organic Chemistry and
Director of the Christian Doppler Laboratory for Microwave Chemistry (CDLMC) at
the University of Graz, Austria. He received his diploma- (1989) and his
doctoral (1992) degrees in organic chemistry from the University of Graz where
he worked with Professor Gert Kollenz on cycloaddition and rearrangement
reactions of acylketenes. After periods of postdoctoral research work on
reactive intermediates and matrix isolation spectroscopy with Professor Curt
Wentrup at the University of Queensland in Brisbane, Australia (1993-1994) and
on synthetic methodology/alkaloid synthesis with Professor Albert Padwa at
Emory University in Atlanta, USA (1994-1996), he moved back to the University
of Graz in 1996 to start his independent academic career. He obtained his
"Habilitation" in 1998 in organic chemistry and was appointed
Associate Professor in 1999. Since 2011 he holds the position of Professor of
"Technology of Organic Synthesis" (Organische Synthesetechnologie) at
the University of Graz. He has spent time as visiting scientist/professor at
e.g. the Scripps Research Institute (La Jolla, USA, Professor K. Barry
Sharpless, 2003), the Toyko Institute of Technology (Toyko, Japan, Professor T.
Takahashi, 2008), the University of Sassari (Sassari, Italy, 2008), and the
Sanford-Burnham Institute for Medical Research (Orlando, USA, 2010). <o:p></o:p></span></p>
<p class=intro style='margin-left:7.5pt;text-align:justify;line-height:10.5pt'><span
lang=EN-US> </span><span lang=EN-US style='font-size:11.0pt'>The co-author of
more than 250 publications, his main research interests have in the past
focused on multicomponent reactions, combinatorial chemistry and the synthesis
of biologically active heterocycles. More recently his research group has been
involved with enabling technologies for synthesis, including microwave and
continuous flow chemistry. During the last few years his lab has authored ~100
original research articles, reviews and book chapters on microwave-assisted
synthesis. His latest book "<i>Practical Microwave Synthesis for Organic
Chemists - Strategies, Instruments, and Protocols</i>" (co-authored with
D. Dallinger and S. S. Murphree) was published with Wiley-VCH in 2009 and is
currently considered one of the standard reference works in the field. For his
innovative work in microwave chemistry he received the 2004 Prous Science Award
from the European Federation for Medicinal Chemistry and the 2010 Houska Prize
in addition to a number of other awards.</span><span lang=EN-US><o:p></o:p></span></p>
<p style='text-align:justify'><span lang=EN-US style='font-size:11.0pt'><o:p> </o:p></span></p>
<p style='text-align:justify'><span lang=EN-US style='font-size:11.0pt'>C.
Oliver Kappe is currently Editor-in-Chief of the Journal of Flow Chemistry
(Akadémiai Kiadó) and a member of the Flow Chemistry Society. He is also a
board member of the International Society of Heterocyclic Chemistry and The
Society of Combinatorial Sciences. In addition he has been an Editor of the
Journal <i>QSAR and Combinatorial Sciences</i> (Wiley-VCH, 2003-2007) and has
served/serves on the Editorial/Advisory Boards of the <i>Journal of
Combinatorial Chemistry</i> (ACS), <i>Molecular Diversity</i> (Springer), <i>ChemMedChem</i>
and <i>ChemSusChem</i> (Wiley-VCH), <i>Journal of Heterocyclic Chemistry</i>
(Wiley-VCH) and a number of other journals.<o:p></o:p></span></p>
<p style='text-align:justify;mso-line-height-alt:10.5pt'><span lang=EN-US
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;text-indent:35.4pt;line-height:normal'><span lang=EN-US
style='font-size:9.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-US style='color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-US style='color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal'><span lang=EN-US style='font-size:12.0pt;
font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:0cm;margin-right:2.55pt;
margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;
text-indent:35.45pt;line-height:150%'><span lang=EN-US style='font-size:12.0pt;
line-height:150%;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal style='mso-margin-top-alt:0cm;margin-right:2.55pt;
margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;
text-indent:35.45pt;line-height:150%'><span lang=EN-US style='font-size:12.0pt;
line-height:150%;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;text-indent:35.4pt;line-height:normal'><span lang=EN-US
style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;text-indent:35.4pt;line-height:normal'><span lang=EN-US
style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p>
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