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<b>Martes </b>20 de septiembre 13 Hs. en el aula de seminarios.<br><br>
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Damian Refojo, MD, PhD "Futuro miembro del IBioBA-Max Planck Partner
Institute" Molecular Neurobiology Max Planck Institute of
Psychiatry, Munich, Germany. Future member of the IBioBA-Max Planck
Partner Institute.
Titulo: "Neurotransmitter-specific conditional knock-outs o como
eliminar un gen in vivo en determinados circuitos de neurotransmisores:
el ejemplo de CRHR1 y sus efectos sobre neurotransmisión y conducta
emocional"
Abstract: The corticotropin-releasing hormone receptor 1 (CRHR1)
critically controls behavioral adaptation to stress and is causally
linked to emotional disorders. Using neurochemical and genetic tools we
determined that CRHR1 is expressed in forebrain glutamatergic and
GABAergic as well as in midbrain dopaminegic neurons and in few
serotonergic neurons of the raphe. We generated different
neurotransmitter-specific CRHR1 conditional knock-out lines where the
CRHR1 gen is deleted in specific brain areas and only in glutamatergic,
GABAergic, dopaminergic and serotonergic neurons in vivo. We found that
the lack of CRHR1 in forebrain glutamatergic circuits reduces anxiety and
impairs neurotransmission in amygdala and hippocampus. Interestingly,
selective deletion of CRHR1 in midbrain dopaminergic neurons increases
anxiety-like behavior and reduces dopamine release in the prefrontal
cortex. These results define a new bidirectional model for the role of
CRHR1 in anxiety and suggest that an imbalance between CRHR1-controlled
anxiogenic glutamatergic and anxiolytic dopaminergic systems might lead
to emotional disorders.
Host: Urbano
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