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Jueves 30 de junio<b> </b>13 Hs. en el aula de seminarios.<br>
<br>
Marcelo Rubinstein<br>
<br>
<b><u>Titulo:</u></b> Bases neurogenéticas de conductas apetitivas y
adictivas: autoreceptores y control de la neurotransmisión
dopaminérgica<br>
<br>
<b><u>Resumen</u></b>: Dopamine (DA) D2 receptors expressed in DA neurons
(D2 autoreceptors) exert a negative feedback regulation that reduces DA
neuron firing, DA synthesis and release. Since D2 receptors are mostly
expressed in postsynaptic neurons, pharmacological and genetic approaches
have been unable to definitively address the in vivo contribution of D2
autoreceptors to DA-mediated behaviors. During this talk I will report
that midbrain DA neurons from mutant mice deficient in D2 autoreceptors
(autoDrd2–/–) lack DA-mediated somatodendritic synaptic responses and
inhibition of DA release. AutoDrd2–/– mice display elevated DA synthesis
and release, hyperlocomotion and supersensitivity to the psychomotor
effects of cocaine. AutoDrd2–/– mice also exhibit increased place
preference for cocaine and enhanced motivation for food reward. This
study highlights the importance of D2 autoreceptors in motor function,
food seeking behavior and sensitivity to the locomotor and rewarding
properties of cocaine and suggests that individual variation in D2
autoreceptor expression could influence personality traits and be
involved in drug addiction, impulsivity and schizophrenia.<br>
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Host: Alejandro Colman Lerner<br>
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