<div class="gmail_quote"><br><br><div class="gmail_quote"><div class="gmail_quote">
<p class="MsoNormal" align="center" style="margin-top:0in;margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:28.0pt;text-autospace:none"><span style="font-size:20.0pt;font-family:ComicSansMS;color:#3B7C46"><b>Seminario
de Química Orgánica 2010</b></span><span style="font-size:20.0pt;font-family:ArialMT"></span></p>
<p class="MsoNormal" align="center" style="margin-right:1.0in;text-align:center;line-height:14.0pt;text-autospace:none"><span style="font-family:Garamond"><b> </b></span><span style="font-size:13.0pt;font-family:ArialMT"></span></p>
<p class="MsoNormal" align="center" style="margin-right:1.0pt;text-align:center;line-height:20.0pt;text-autospace:none"><span style="font-size:17.0pt;font-family:Garamond;color:#001078"><b>
28 de Abril de 2010 </b></span><span style="font-size:17.0pt;color:#001078"><b>―</b></span><span style="font-size:17.0pt;font-family:Garamond;color:#001078"><b> 13:00 horas</b></span></p>
<p class="MsoNormal" align="center" style="margin-right:1.0pt;text-align:center;line-height:20.0pt;text-autospace:none"><span style="font-size:17.0pt;font-family:Garamond;color:#DA211F"><b>Aula
de Seminarios </b></span></p>
<p class="MsoNormal" align="center" style="margin-right:1.0pt;text-align:center;line-height:20.0pt;text-autospace:none"><span style="font-size:17.0pt;font-family:Garamond;color:#DA211F"><b>Departamento
de Química Orgánica</b></span></p><p class="MsoNormal" align="center" style="margin-right:1.0pt;text-align:center;line-height:20.0pt;text-autospace:none"><span style="font-size:17.0pt;font-family:Garamond;color:#DA211F"><b><span style="color:rgb(0, 0, 0);font-family:arial;font-size:small;font-weight:normal;line-height:normal"><span style="font-size:19.0pt;font-family:Garamond"><b>Expositor: </b></span><span style="font-size:18.0pt;font-family:Garamond"><b>Claudio Fernandez</b></span></span></b></span></p>
<p class="MsoNormal" align="center" style="text-align:center;text-autospace:none"><font class="Apple-style-span" face="Garamond" size="6"><span class="Apple-style-span" style="font-size: 24px;"><b>
</b></span></font></p><font class="Apple-style-span" face="Garamond" size="6"><b><pre><span style="font-family: Arial; "><span class="Apple-style-span" style="font-size: large;">Instituto de Biología Molecular y Celular de Rosario </span></span></pre>
</b></font><p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:17.0pt;font-family:Garamond"><b><font color="#000099">Título: <span class="Apple-style-span" style="font-size: large;"><font class="Apple-style-span" face="arial, helvetica, sans-serif">Structural Biology and
Bioinorganic Chemistry of Parkinson’s disease<span class="Apple-style-span" style="color: rgb(0, 0, 0); font-family: Helvetica; font-size: 21px; font-weight: normal; "> </span></font></span></font></b></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-family:Helvetica"> </span></p>
<p class="MsoNormal" style="text-align:left;margin-top:0in;margin-bottom:0.0001pt;line-height:28pt"><span style="font-size:20.0pt;font-family:ComicSansMS;color:#3B7C46"><b><span style="color:rgb(0, 0, 0);font-family:arial;font-size:small;font-weight:normal;line-height:normal"><span style="font-size:16.0pt;font-family:Garamond"><b>Resumen</b></span><span style="font-size:16.0pt;font-family:Garamond">: <font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: large;">The aggregation of alpha-synuclein (AS) is a critical step in the
etiology of Parkinson’s disease
(PD) and other neurodegenerative synucleinopathies. Protein-metal interactions
play a critical role in AS aggregation and might represent the link</span></font><span style="color:red"><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: large;"> </span></font></span><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: large;">between the pathological processes of protein
aggregation and oxidative damage. On the other hand, the identification of
aggregation inhibitors and the investigation of their mechanism of action are
fundamental in the quest to mitigate the pathological consequences of amyloid
formation. By the combined application of Nuclear Magnetic Resonance (NMR),
Electron Paramagnetic Resonance (EPR), Mass Spectrometry (MALDI-MS), UV-visible
spectroscopy and Circular Dichrosim (CD) we have addressed structural
unresolved details related to the binding specificity of metal-AS interactions
and the mechanistic rules that direct the anti-amyloid effect of small
molecules on AS fibril formation. These results will be the focus of the
present talk.</span></font></span></span></b></span></p>
<p class="MsoNormal" style="text-align:justify"><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: large;"> </span></font><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: large;"></span></font></p>
<p class="MsoNormal" style="margin-left:-13.5pt;text-align:justify;text-indent:
13.5pt;line-height:12.0pt;mso-line-height-rule:exactly;mso-list:l0 level1 lfo1;
tab-stops:list -13.5pt;text-autospace:none"><span lang="ES"><b><font class="Apple-style-span" face="garamond, serif">1.</font><span style="font:7.0pt "Times New Roman""><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: small;">
</span></font></span></b></span><span lang="ES"><font class="Apple-style-span" face="garamond, serif">Rasia </font><i><font class="Apple-style-span" face="garamond, serif">et al.</font></i></span><span lang="ES"><font class="Apple-style-span" face="garamond, serif"> (2005) </font><i><font class="Apple-style-span" face="garamond, serif">Proc Natl Acad Sci U S A</font></i></span><span lang="ES"><font class="Apple-style-span" face="garamond, serif"> 102: 4294-4299.</font><i><font class="Apple-style-span" face="garamond, serif"></font></i></span></p>
<p class="MsoNormal" style="margin-left:-13.5pt;text-align:justify;text-indent:
13.5pt;line-height:12.0pt;mso-line-height-rule:exactly;mso-list:l0 level1 lfo1;
tab-stops:list -13.5pt;text-autospace:none"><span lang="EN-GB"><b><font class="Apple-style-span" face="garamond, serif">2.</font><span style="font:7.0pt "Times New Roman""><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: small;">
</span></font></span></b></span><span lang="ES"><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16866548&query_hl=4&itool=pubmed_docsum"><span lang="EN-GB" style="color:windowtext;mso-ansi-language:EN-GB;text-decoration:
none;text-underline:none"><font class="Apple-style-span" face="garamond, serif">Binolfi</font></span><span lang="EN-GB" style="color:windowtext;
mso-ansi-language:EN-US;text-decoration:none;text-underline:none"><font class="Apple-style-span" face="garamond, serif"> </font></span><span lang="EN-US" style="color:windowtext;mso-ansi-language:EN-US;text-decoration:
none;text-underline:none"><i><font class="Apple-style-span" face="garamond, serif">et al</font></i></span><span lang="EN-GB" style="color:
windowtext;mso-ansi-language:EN-GB;text-decoration:none;text-underline:none"><font class="Apple-style-span" face="garamond, serif">.</font></span></a></span><span lang="ES"><font class="Apple-style-span" face="garamond, serif"> </font></span><span lang="EN-GB" style="color: black; "><font class="Apple-style-span" face="garamond, serif">(2006) </font></span><span lang="EN-GB"><i><font class="Apple-style-span" face="garamond, serif">J Am Chem Soc.</font></i></span><span lang="EN-GB"><font class="Apple-style-span" face="garamond, serif">
128:9893-9901.</font><i><font class="Apple-style-span" face="garamond, serif"></font></i></span></p>
<p class="MsoNormal" style="margin-left:-13.5pt;text-align:justify;text-indent:
13.5pt;line-height:12.0pt;mso-line-height-rule:exactly;mso-list:l0 level1 lfo1;
tab-stops:list -13.5pt;text-autospace:none"><b><font class="Apple-style-span" face="garamond, serif">3.</font><span style="font:7.0pt "Times New Roman""><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: small;">
</span></font></span></b><font class="Apple-style-span" face="garamond, serif">Binolfi </font><i><font class="Apple-style-span" face="garamond, serif">et al</font></i><font class="Apple-style-span" face="garamond, serif">. </font><span style="color:black"><font class="Apple-style-span" face="garamond, serif">(2008)
</font></span><i><font class="Apple-style-span" face="garamond, serif">J Am Chem Soc.</font></i><font class="Apple-style-span" face="garamond, serif"> 130: 11801-11812.</font><font class="Apple-style-span" face="garamond, serif"></font></p>
<p class="MsoNormal" style="margin-left:-13.5pt;text-align:justify;text-indent:
13.5pt;line-height:12.0pt;mso-line-height-rule:exactly;mso-list:l0 level1 lfo1;
tab-stops:list -13.5pt;text-autospace:none"><span lang="ES"><b><font class="Apple-style-span" face="garamond, serif">4.</font><span style="font:7.0pt "Times New Roman""><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: small;">
</span></font></span></b></span><span lang="ES"><font class="Apple-style-span" face="garamond, serif">Lamberto </font><i><font class="Apple-style-span" face="garamond, serif">et al.</font></i></span><span lang="ES"><font class="Apple-style-span" face="garamond, serif"> (2009) </font><i><font class="Apple-style-span" face="garamond, serif">Proc Natl Acad Sci U S A</font></i></span><span lang="ES"><font class="Apple-style-span" face="garamond, serif"> 106: 21057-21062.</font><font class="Apple-style-span" face="garamond, serif"><span class="Apple-style-span" style="font-size: large;"></span></font></span></p>
<p class="MsoNormal" align="center" style="margin-top:0in;margin-bottom:0in;margin-bottom:.0001pt;text-align:center;line-height:28.0pt;text-autospace:none">
<span style="line-height:normal"><font color="#3B7C46" face="ComicSansMS" size="7"><span style="font-size:27px;line-height:37px"><b><br></b></span></font></span></p>
</div><br>
</div><br>
</div><br>