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SEMINARIOS DQIAQF/ INQUIMAE 2009<o:p></o:p></FONT></SPAN>
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</SPAN><U>MARTES</U> 18 de Agosto de
2009-<U>13hs<o:p></o:p></U></SPAN></FONT></B></P>
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</SPAN>Aula de Seminarios del INQUIMAE, <SPAN class=SpellE>Pab</SPAN>. II Piso
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IL 60208</SPAN></FONT><SPAN lang=EN-GB
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style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">One
of the major challenges in drug delivery is the ability to target
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style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">without<SPAN
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style="mso-spacerun: yes"> </SPAN>with<SPAN
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face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">delivery.<SPAN
style="mso-spacerun: yes"> </SPAN>In this presentation we<SPAN
style="mso-spacerun: yes"> </SPAN>show<SPAN
style="mso-spacerun: yes"> </SPAN>how<SPAN
style="mso-spacerun: yes"> </SPAN>we can take<SPAN
style="mso-spacerun: yes"> </SPAN>advantage<SPAN
style="mso-spacerun: yes"> </SPAN>of the<SPAN
style="mso-spacerun: yes"> </SPAN>modification</SPAN></FONT><SPAN
lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 349.45pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 349.45pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">that<SPAN
style="mso-spacerun: yes"> </SPAN>occur<SPAN
style="mso-spacerun: yes"> </SPAN>on<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>plasma<SPAN
style="mso-spacerun: yes"> </SPAN>membrane<SPAN
style="mso-spacerun: yes"> </SPAN>of<SPAN
style="mso-spacerun: yes"> </SPAN>cancer<SPAN
style="mso-spacerun: yes"> </SPAN>cells<SPAN
style="mso-spacerun: yes"> </SPAN>to<SPAN
style="mso-spacerun: yes"> </SPAN>target<SPAN
style="mso-spacerun: yes"> </SPAN>surface<SPAN
style="mso-spacerun: yes"> </SPAN>modified</SPAN></FONT><SPAN
lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 367.35pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 367.35pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">nanoparticles.
The basic idea is to take advantage of the over-expressed receptors and
the</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 384.05pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 384.05pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">different
lipid composition of the plasma membrane<SPAN
style="mso-spacerun: yes"> </SPAN>in (some) cancer cells. To this
end</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 401.9pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 401.9pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">we<SPAN
style="mso-spacerun: yes"> </SPAN>show,<SPAN
style="mso-spacerun: yes"> </SPAN>as<SPAN
style="mso-spacerun: yes"> </SPAN>a<SPAN
style="mso-spacerun: yes"> </SPAN>proof<SPAN
style="mso-spacerun: yes"> </SPAN>of<SPAN
style="mso-spacerun: yes"> </SPAN>concept,<SPAN
style="mso-spacerun: yes"> </SPAN>how<SPAN
style="mso-spacerun: yes"> </SPAN>modifying the<SPAN
style="mso-spacerun: yes"> </SPAN>surface of<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>nanoparticles<SPAN
style="mso-spacerun: yes"> </SPAN>with</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 419.85pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 419.85pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">binary<SPAN
style="mso-spacerun: yes"> </SPAN>mixtures<SPAN
style="mso-spacerun: yes"> </SPAN>of<SPAN
style="mso-spacerun: yes"> </SPAN>short<SPAN
style="mso-spacerun: yes"> </SPAN>polymers<SPAN
style="mso-spacerun: yes"> </SPAN>can<SPAN
style="mso-spacerun: yes"> </SPAN>increase<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>binding<SPAN
style="mso-spacerun: yes"> </SPAN>to<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>cells<SPAN
style="mso-spacerun: yes"> </SPAN>by<SPAN
style="mso-spacerun: yes"> </SPAN>orders<SPAN
style="mso-spacerun: yes"> </SPAN>of</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 437.75pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 437.75pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">magnitude.
One<SPAN style="mso-spacerun: yes"> </SPAN>of the polymers<SPAN
style="mso-spacerun: yes"> </SPAN>in<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>mixture<SPAN
style="mso-spacerun: yes"> </SPAN>is aimed<SPAN
style="mso-spacerun: yes"> </SPAN>at protecting the<SPAN
style="mso-spacerun: yes"> </SPAN>nanoparticle</SPAN></FONT><SPAN
lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 455.7pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 455.7pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">and
the other is a polybase with a functional ligand as its end-group that
specific targets</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 473.65pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 473.65pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">the<SPAN
style="mso-spacerun: yes"> </SPAN>overexpressed<SPAN
style="mso-spacerun: yes"> </SPAN>receptors<SPAN
style="mso-spacerun: yes"> </SPAN>in<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>cancer<SPAN
style="mso-spacerun: yes"> </SPAN>cell.<SPAN
style="mso-spacerun: yes"> </SPAN>We<SPAN
style="mso-spacerun: yes"> </SPAN>show<SPAN
style="mso-spacerun: yes"> </SPAN>how<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>combination<SPAN
style="mso-spacerun: yes"> </SPAN>of</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 490.25pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 490.25pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">electrostatic<SPAN
style="mso-spacerun: yes"> </SPAN>interactions,<SPAN
style="mso-spacerun: yes"> </SPAN>specific<SPAN
style="mso-spacerun: yes"> </SPAN>binding,<SPAN
style="mso-spacerun: yes"> </SPAN>acid-base<SPAN
style="mso-spacerun: yes"> </SPAN>equilibrium<SPAN
style="mso-spacerun: yes"> </SPAN>and<SPAN
style="mso-spacerun: yes"> </SPAN>molecular</SPAN></FONT><SPAN
lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 508.15pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 508.15pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">organization<SPAN
style="mso-spacerun: yes"> </SPAN>in<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>nanoparticle<SPAN
style="mso-spacerun: yes"> </SPAN>and<SPAN
style="mso-spacerun: yes"> </SPAN>on<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>lipid<SPAN
style="mso-spacerun: yes"> </SPAN>layer<SPAN
style="mso-spacerun: yes"> </SPAN>provides<SPAN
style="mso-spacerun: yes"> </SPAN>for<SPAN
style="mso-spacerun: yes"> </SPAN>a<SPAN
style="mso-spacerun: yes"> </SPAN>non-trivial</SPAN></FONT><SPAN
lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 526.1pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 526.1pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">synergetic<SPAN
style="mso-spacerun: yes"> </SPAN>effect<SPAN
style="mso-spacerun: yes"> </SPAN>with <SPAN
style="mso-spacerun: yes"> </SPAN>highly<SPAN
style="mso-spacerun: yes"> </SPAN>improved<SPAN
style="mso-spacerun: yes"> </SPAN>binding<SPAN
style="mso-spacerun: yes"> </SPAN>capabilities.<SPAN
style="mso-spacerun: yes"> </SPAN>We<SPAN
style="mso-spacerun: yes"> </SPAN>will<SPAN
style="mso-spacerun: yes"> </SPAN>show<SPAN
style="mso-spacerun: yes"> </SPAN>how<SPAN
style="mso-spacerun: yes"> </SPAN>the</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 544.05pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 544.05pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">approach<SPAN
style="mso-spacerun: yes"> </SPAN>of<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>nanoparticle<SPAN
style="mso-spacerun: yes"> </SPAN>to<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>lipid<SPAN
style="mso-spacerun: yes"> </SPAN>layer<SPAN
style="mso-spacerun: yes"> </SPAN>results<SPAN
style="mso-spacerun: yes"> </SPAN>in<SPAN
style="mso-spacerun: yes"> </SPAN>a<SPAN
style="mso-spacerun: yes"> </SPAN>highly<SPAN
style="mso-spacerun: yes"> </SPAN>inhomogeneous</SPAN></FONT><SPAN
lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 560.65pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 560.65pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">segregation<SPAN
style="mso-spacerun: yes"> </SPAN>of<SPAN
style="mso-spacerun: yes"> </SPAN>lipids<SPAN
style="mso-spacerun: yes"> </SPAN>in<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>cell<SPAN
style="mso-spacerun: yes"> </SPAN>membrane<SPAN
style="mso-spacerun: yes"> </SPAN>and<SPAN
style="mso-spacerun: yes"> </SPAN>of<SPAN
style="mso-spacerun: yes"> </SPAN>polymers<SPAN
style="mso-spacerun: yes"> </SPAN>in<SPAN
style="mso-spacerun: yes"> </SPAN>the<SPAN
style="mso-spacerun: yes"> </SPAN>nanoparticle.<SPAN
style="mso-spacerun: yes"> </SPAN>The</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 578.55pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
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style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 578.55pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">molecular<SPAN
style="mso-spacerun: yes"> </SPAN>segregation<SPAN
style="mso-spacerun: yes"> </SPAN>can<SPAN
style="mso-spacerun: yes"> </SPAN>be<SPAN
style="mso-spacerun: yes"> </SPAN>used<SPAN
style="mso-spacerun: yes"> </SPAN>as<SPAN
style="mso-spacerun: yes"> </SPAN>a<SPAN
style="mso-spacerun: yes"> </SPAN>tool<SPAN
style="mso-spacerun: yes"> </SPAN>not<SPAN
style="mso-spacerun: yes"> </SPAN>only<SPAN
style="mso-spacerun: yes"> </SPAN>for<SPAN
style="mso-spacerun: yes"> </SPAN>drug<SPAN
style="mso-spacerun: yes"> </SPAN>delivery<SPAN
style="mso-spacerun: yes"> </SPAN>but<SPAN
style="mso-spacerun: yes"> </SPAN>also<SPAN
style="mso-spacerun: yes"> </SPAN>for</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
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<TR>
<TD
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vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 596.5pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">molecular
recognition of surface domains. The implication of our findings in terms
of the</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
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<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 614.45pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">complex<SPAN
style="mso-spacerun: yes"> </SPAN>non-additive interplay
between<SPAN style="mso-spacerun: yes"> </SPAN>chemical
reactions<SPAN style="mso-spacerun: yes"> </SPAN>and physical
interactions<SPAN style="mso-spacerun: yes">
</SPAN>in</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
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<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
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<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 632.3pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">highly
inhomogeneous environments<SPAN style="mso-spacerun: yes"> </SPAN>to
the design of responsive systems as well as the</SPAN></FONT><SPAN
lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<DIV
style="mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 648.95pt; mso-height-rule: exactly">
<TABLE cellSpacing=0 cellPadding=0 vspace="0" hspace="0">
<TBODY>
<TR>
<TD
style="PADDING-RIGHT: 0cm; PADDING-LEFT: 0cm; PADDING-BOTTOM: 0cm; PADDING-TOP: 0cm"
vAlign=top align=left>
<P class=MsoNormal
style="TEXT-ALIGN: justify; mso-element: frame; mso-element-wrap: auto; mso-element-anchor-vertical: page; mso-element-anchor-horizontal: page; mso-element-left: 120.3pt; mso-element-top: 648.95pt; mso-height-rule: exactly; mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" color=black size=4><SPAN lang=EN-GB
style="FONT-SIZE: 15pt; COLOR: black; LETTER-SPACING: -0.05pt; mso-ansi-language: EN-GB">fundamental
understanding of molecular cell biology will be
discussed.</SPAN></FONT><SPAN lang=EN-GB
style="mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
<P class=MsoNormal
style="mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" size=3><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; mso-ansi-language: EN-GB"><SPAN
style="mso-spacerun: yes"> </SPAN><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal
style="mso-pagination: none; mso-layout-grid-align: none"><FONT
face="Times New Roman" size=3><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; mso-ansi-language: EN-GB"><o:p> </o:p></SPAN></FONT></P>
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style="mso-pagination: none; mso-layout-grid-align: none"><FONT
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