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Seminario <b>miércoles </b>18 de marzo, <b>13 hs</b>. Aula de seminarios
del LFBM<br>
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DFBMC e IFIBYNE: Dr. Genís Parra Farré<br>
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Genís Parra Farré<br>
Genome Center. University of California Davis.<br>
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<b>"Intron Mediated Enhancement of gene expression"<br>
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</b>Shortly after introns were discovered, it was noted that several
genes were expressed very poorly when their introns were removed. Introns
that elevate mRNA accumulation have been found in a wide range of
eukaryotes. This phenomenon is called intron mediated enhancement (IME).
The mechanism of IME is largely unknown but it is not <br>
due to traditional transcriptional enhancers embedded in introns.
However, not all introns affect gene expression, and direct testing is
currently the only way to identify stimulatory introns. Our genome-wide
analysis in A.thaliana revealed that promoter-proximal introns as a group
are compositionally distinct from distal introns and that the degree to
which an individual intron matches the promoter-proximal intron profile
is a strong predictor of its ability to enhance expression. We extended
this analysis to some vertebrate species to find out interesting
similarities.<br>
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Host: Alberto Kornblihtt<br>
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