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<DIV align=center><FONT size=5><STRONG>Miércoles 20 de agosto de 2008 - 13
hs<BR><BR></STRONG>Aula de Seminarios del INQUIMAE, 3er piso Pab. II
<BR><BR><BR></FONT><B>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><SPAN lang=EN-US style="FONT-SIZE: 10pt"><FONT size=6>Dr Randy
Duran<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office"
/><o:p></o:p></FONT></SPAN></P><BR>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><SPAN lang=EN-US style="FONT-SIZE: 10pt"><FONT size=5>Department of
Chemistry<o:p></o:p></FONT></SPAN></P>
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align=center><FONT size=5><?xml:namespace prefix = st1 ns =
"urn:schemas-microsoft-com:office:smarttags" /><st1:place><st1:PlaceType><SPAN
lang=EN-US style="FONT-SIZE: 10pt">University</SPAN></st1:PlaceType><SPAN
lang=EN-US style="FONT-SIZE: 10pt"> of </SPAN><st1:PlaceName><SPAN lang=EN-US
style="FONT-SIZE: 10pt">florida</SPAN></st1:PlaceName></st1:place><SPAN
lang=EN-US style="FONT-SIZE: 10pt"><o:p></o:p></SPAN></FONT></P>
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align=center><st1:place><FONT size=5><st1:City><SPAN lang=EN-US
style="FONT-SIZE: 10pt">Gainesville</SPAN></st1:City><SPAN lang=EN-US
style="FONT-SIZE: 10pt">, </SPAN><st1:State><SPAN lang=EN-US
style="FONT-SIZE: 10pt">FL</SPAN></st1:State><SPAN lang=EN-US
style="FONT-SIZE: 10pt"> </SPAN><st1:PostalCode><SPAN lang=EN-US
style="FONT-SIZE: 10pt">32611</SPAN></st1:PostalCode></FONT></st1:place></P><BR><FONT
size=1><BR></B></FONT></DIV>
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<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><FONT face="Times New Roman"><FONT size=5><SPAN lang=EN-US
style="FONT-SIZE: 16pt; FONT-FAMILY: Arial">Interfacing Ion Channels to
Microelectronics: Comparing Single Channel Activities from Four
Systems</SPAN><SPAN lang=EN-US
style="DISPLAY: none; FONT-SIZE: 16pt; FONT-FAMILY: 'Arial Unicode MS'; mso-fareast-font-family: 'Times New Roman'; mso-hide: all"><o:p></o:p></SPAN></FONT></FONT></P></o:p></SPAN>
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lang=EN-US><o:p> </o:p></SPAN><SPAN lang=EN-US><o:p> </o:p></SPAN></P>
<P class=PreprintBody style="MARGIN: 0cm 0cm 0pt" align=justify><SPAN lang=EN-US
style="FONT-SIZE: 12pt">As part of a project centered on functionally
incorporating ion channels in non-native and polymer- stabilized lipid bilayers,
we are interested in characterizing the ion translocation behavior of the
resulting assemblies.<SPAN style="mso-spacerun: yes"> </SPAN>We have
investigated several ion-channels with a view towards using them in tethered
bilayers over microelectronic devices for eventual biosensor applications.<SPAN
style="mso-spacerun: yes"> </SPAN>The ion channel characteristics and
their functional incorporation in bilayers will be presented.<SPAN
style="mso-spacerun: yes"> </SPAN>Single channel ion current fluctuations
were measured by several methods and these data will be discussed.<SPAN
style="mso-spacerun: yes"> </SPAN>Finally methods to tether the ion
channel/lipid bilayer assembly to solid state devices and protein-based
techniques for stabilization will be presented. <o:p></o:p></SPAN></P>
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style="FONT-SIZE: 12pt"><o:p><FONT
face=Arial> </FONT></o:p></SPAN></P><BR><BR>
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