<html>
<blockquote type=cite cite>Fecha: martes 10 de junio, 13hs en el Aula de
Seminarios del LFBM <br>
<br>
Estimados todos,<br>
<br>
Este <b><u>martes 10 de junio </u></b>tendremos el agrado de recibir al
Dr. Enrico Stefani y la Dra. Ligia Toro. El seminario se llevará acabo
en el <b>aula de seminarios del LFBM</b>, 2do piso, Pabellon II de Ciudad
Universitaria. Les vamos adelantando la información respectiva:<br>
<br>
<b><u>Enrico Stefani MD, PhD<br>
</u></b>Departments of Anesthesiology and Physiology, University of
California , Los Angeles<br>
Distinguished Professor<br>
Vice Chair of Research, Dept. Anesthesiology<br>
Director, Division of Molecular Medicine<br>
Associate Director, Cardiovascular Research Laboratories<br>
<br>
<b><u>Titulo: "Heart Estrogen, Estrogen Receptors and
Cardioprotection"</u></b><br>
<br>
Resumen: Females in the reproductive age are more susceptible to cardiac
arrhythmias but they have a lower risk of cardiac disease. We are
investigating the mechanism(s) underlying this paradoxical
phenomenon. We discover that heart can locally synthesize estrogen
via the conversion of testosterone by aromatase activity. Heart
estrogen is higher in females than in males downregulating K repolarizing
currents which explains the higher susceptibility of females to cardiac
arrhythmia. At the same time, heart estrogen activates protective
signaling cascades reducing the risk of heart failure under stress.
Furthermore, estrogen treatment in heart failure by pressure overload
rescues the failing heart by reversing the pathological gene expression
profile. The role of the various molecules including ion channels and
signaling cascades will be discussed in relation to the mechanisms of
estrogen induced arrythmogenesis and cardio-protection.<br>
<br>
<br>
<b><u>Ligia Toro, PhD</u></b><br>
Division of Molecular Medicine, Department of Anesthesiology, <br>
and Department of Molecular & Medical Pharmacology<br>
Professor<br>
University of California , Los Angeles<br>
<b><u>TÃtulo: "Physiological roles of MaxiK
channels"</u></b><br>
<br>
Resúmen: MaxiK channels are key regulators of several body
functions, including neuronal excitability, uresis, reproduction and
blood pressure. Our laboratory has been interested in deciphering basic
mechanisms of how MaxiK channels and associated proteins work in concert
to regulate blood pressure in health and during aging. I will discuss
evidence of new mechanisms by which these ion channels may regulate
vasoconstriction including regulation and association with G-protein
coupled receptors, long-term genomic regulation by estrogen, and
mechanisms of protein targeting. <br>
<br>
<br>
<br>
<br>
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