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<DIV align=center><FONT face=Arial size=6>Horario de Seminario: 14
horas</FONT></DIV>
<DIV align=center><FONT face=Arial size=5></FONT> </DIV>
<P class=MsoNormal
style="MARGIN: 0cm -15.8pt 0pt 0cm; TEXT-ALIGN: center; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto"
align=center><B><SPAN
style="FONT-SIZE: 22pt; COLOR: blue; FONT-FAMILY: Arial; mso-bidi-font-family: 'Times New Roman'">SEMINARIO
DE QUÍMICA ORGÁNICA <?xml:namespace prefix = o ns =
"urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></B></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto"
align=center><B style="mso-bidi-font-weight: normal"><U><SPAN lang=ES-AR
style="FONT-SIZE: 12pt; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><A
href="http://www.qo.fcen.uba.ar/Cursos/semin.htm"><SPAN
style="COLOR: windowtext">http://www.qo.fcen.uba.ar/Cursos/semin.htm</SPAN></A><o:p></o:p></SPAN></U></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><FONT size=2><B><SPAN lang=PT-BR
style="COLOR: blue; FONT-FAMILY: Arial; mso-ansi-language: PT-BR">Miércoles 10
de octubre, 14 hs. Aula Dr. Venancio Deulofeu, Departamento de Química
Orgánica</SPAN></B><SPAN lang=PT-BR
style="FONT-SIZE: 12pt; mso-ansi-language: PT-BR"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><FONT size=2><B><SPAN lang=ES-AR
style="COLOR: blue; FONT-FAMILY: Arial; mso-ansi-language: ES-AR">Ciudad
Universitaria, Pab. II, Piso 3</SPAN></B><SPAN lang=ES-AR
style="FONT-SIZE: 12pt; mso-ansi-language: ES-AR"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN lang=ES-AR
style="FONT-SIZE: 8pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><o:p> </o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN lang=IT
style="FONT-SIZE: 20pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: IT">Dr.
</SPAN></B><B style="mso-bidi-font-weight: normal"><SPAN lang=IT
style="FONT-SIZE: 20pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">Chryssostomos
Chatgilialoglu</SPAN></B><B><SPAN lang=IT
style="FONT-SIZE: 20pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: IT"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN lang=IT
style="FONT-SIZE: 8pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: IT"><o:p> </o:p></SPAN></B></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 200%; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><I
style="mso-bidi-font-style: normal"><SPAN lang=IT
style="FONT-SIZE: 16pt; LINE-HEIGHT: 200%; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">ISOF,
Consiglio Nazionale delle Ricerche, Bologna, Italy</SPAN></I></B><B
style="mso-bidi-font-weight: normal"><SPAN lang=IT
style="FONT-SIZE: 16pt; LINE-HEIGHT: 200%; FONT-FAMILY: Arial; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 'MS Gothic'; mso-ansi-language: IT; mso-fareast-language: JA">.</SPAN></B><B
style="mso-bidi-font-weight: normal"><I
style="mso-bidi-font-style: normal"><SPAN lang=IT
style="FONT-SIZE: 16pt; LINE-HEIGHT: 200%; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT"><o:p></o:p></SPAN></I></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify"
align=center><SPAN lang=IT
style="FONT-SIZE: 8pt; mso-ansi-language: IT"><o:p> </o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><SPAN lang=EN-US
style="FONT-SIZE: 20pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US">One-electron
reduction of 8-bromopurine nucleosides<o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><SPAN lang=EN-US
style="FONT-SIZE: 20pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US">and
excess electron transfer through DNA</SPAN></B><B
style="mso-bidi-font-weight: normal"><SPAN lang=EN-US
style="FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><SPAN lang=EN-US
style="FONT-SIZE: 24pt; mso-ansi-language: EN-US"><o:p> </o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><SPAN lang=EN-US
style="FONT-SIZE: 8pt; mso-ansi-language: EN-US"><o:p> </o:p></SPAN></B></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 18pt; TEXT-ALIGN: justify"
align=center><SPAN lang=EN-US
style="FONT-SIZE: 16pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US">The
reactions of hydrated electrons (e<SUB>aq</SUB><SUP>–</SUP>) with a variety of
8-bromopurine nucleosides have been investigated by radiolytic methods coupled
with product studies, and addressed computationally by means of DFT-B3LYP
calculations. A different behavior is observed for the defferent purines. The
reactions of e<SUB>aq</SUB><SUP>–</SUP> with a variety of single- and
double-strand oligonucleotides as well as four stranded quadruplex complexes
that contain 8-bromopurine nucleotides have been studied. Our results
demonstrated that some of these bromo-derivatives are very effective in excess
electron transfer and they can behave as an ultimate sink for electrons due to
the Br<SUP>–</SUP> ejection.<o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%"
align=center><SPAN lang=EN-US
style="FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US"><o:p><FONT
size=2> </FONT></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=center><SPAN lang=PT-BR
style="FONT-SIZE: 14pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: PT-BR">References.<o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=justify><SPAN lang=PT-BR
style="FONT-SIZE: 14pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: PT-BR">1)<SPAN
style="mso-tab-count: 1"> </SPAN>Chatgilialoglu, C.; Guerra, M.;
Mulazzani, Q. G. <I style="mso-bidi-font-style: normal">J. Am. Chem. Soc.</I> <B
style="mso-bidi-font-weight: normal">2003</B>, <I
style="mso-bidi-font-style: normal">125</I>, 3839–3848.<o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=justify><SPAN lang=IT
style="FONT-SIZE: 14pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">2)<SPAN
style="mso-tab-count: 1"> </SPAN>Chatgilialoglu, C.; Duca, M.; Ferreri,
C.; Guerra, M.; Ioele, M.; Mulazzani, Q. G.; Strittmatter, H.; Giese, B.<I
style="mso-bidi-font-style: normal"> Chem. Eur. J.</I> <B
style="mso-bidi-font-weight: normal">2004</B>, <I
style="mso-bidi-font-style: normal">10</I>, 1249–1255.<SPAN
style="COLOR: black"><o:p></o:p></SPAN></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=justify><SPAN lang=IT
style="FONT-SIZE: 14pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">3)<SPAN
style="mso-tab-count: 1"> </SPAN>De Champdoré,<SPAN
style="mso-spacerun: yes"> </SPAN>M.; De Napoli, L.; Montesarchio, D.;
Piccialli, G.; Caminal C.; Mulazzani, Q. G.; Navacchia,<SPAN
style="mso-spacerun: yes"> </SPAN>M. L.; Chatgilialoglu, C. <I
style="mso-bidi-font-style: normal">Chem. Commun.</I> <B
style="mso-bidi-font-weight: normal">2004</B>, 1756–1757.<o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=justify><SPAN lang=IT
style="FONT-SIZE: 14pt; COLOR: black; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">4)<SPAN
style="mso-tab-count: 1"> </SPAN>Chatgilialoglu, C.; Caminal C.; Guerra,
M.; Mulazzani, Q. G. <I style="mso-bidi-font-style: normal">Angew. Chem. Int.
Ed.</I> <B style="mso-bidi-font-weight: normal">2005</B>, <I
style="mso-bidi-font-style: normal">44</I>, 6030–6032.</SPAN><SPAN lang=IT
style="FONT-SIZE: 14pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=justify><SPAN lang=IT
style="FONT-SIZE: 14pt; COLOR: black; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">5)<SPAN
style="mso-tab-count: 1"> </SPAN>Manetto, A.; Breeger, S.; Chatgilialoglu,
C.; Carell, T. <I style="mso-bidi-font-style: normal">Angew. Chem. Int. Ed.</I>
<B style="mso-bidi-font-weight: normal">2006</B>, <I
style="mso-bidi-font-style: normal">45</I>, 318–321.<o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=justify><SPAN lang=IT
style="FONT-SIZE: 14pt; COLOR: black; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">6)<SPAN
style="mso-tab-count: 1"> </SPAN></SPAN><SPAN lang=IT
style="FONT-SIZE: 14pt; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">Russo,
M.; Jimenez, L. B.; Mulazzani, Q. G.; D’Angelantonio, M.; Guerra, M.; Miranda,
M. A.; Chatgilialoglu, C. <I style="mso-bidi-font-style: normal">Chem. Eur.
J.</I> <B style="mso-bidi-font-weight: normal">2006</B>, <I
style="mso-bidi-font-style: normal">12</I>, 7684–7693.<o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=justify><SPAN lang=IT
style="FONT-SIZE: 14pt; COLOR: black; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">7)<SPAN
style="mso-tab-count: 1"> </SPAN>Chatgilialoglu, C.; Caminal C.; Altieri,
A.; Mulazzani, Q. G.; Vougioukalakis,<SUP> </SUP>G. C.; Gimisis, T.; Guerra, M.
<I style="mso-bidi-font-style: normal">J.</I> <I
style="mso-bidi-font-style: normal">Am. Chem. Soc.</I> <B
style="mso-bidi-font-weight: normal">2006</B>, <I
style="mso-bidi-font-style: normal">128</I>, 13796–13805.<o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt 18pt; TEXT-INDENT: -18pt"
align=justify><SPAN lang=IT
style="FONT-SIZE: 14pt; COLOR: black; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: IT">8)<SPAN
style="mso-tab-count: 1"> </SPAN>Kaloudis, P., D'Angelantonio, M.,
Gimisis, T., Guerra, M., Mulazzani, Q. G., Chatgilialoglu, C. <I
style="mso-bidi-font-style: normal">J. Am. </I></SPAN><I
style="mso-bidi-font-style: normal"><SPAN
style="FONT-SIZE: 14pt; COLOR: black; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'">Chem.
Soc.</SPAN></I><SPAN
style="FONT-SIZE: 14pt; COLOR: black; FONT-FAMILY: Times; mso-bidi-font-family: 'Times New Roman'">
<B style="mso-bidi-font-weight: normal">2007</B>
submitted.<o:p></o:p></SPAN></P></BODY></HTML>