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align=center><B><SPAN
style="FONT-SIZE: 22pt; COLOR: blue; FONT-FAMILY: Arial; mso-bidi-font-family: 'Times New Roman'">SEMINARIO
DE QUÍMICA ORGÁNICA <?xml:namespace prefix = o ns =
"urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></B></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto"
align=center><B style="mso-bidi-font-weight: normal"><U><SPAN lang=ES-AR
style="FONT-SIZE: 12pt; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><A
href="http://www.qo.fcen.uba.ar/Cursos/semin.htm"><SPAN
style="COLOR: windowtext">http://www.qo.fcen.uba.ar/Cursos/semin.htm</SPAN></A><o:p></o:p></SPAN></U></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN style="COLOR: blue; FONT-FAMILY: Arial">Miércoles 6 de
junio, 13 hs</SPAN></B><SPAN style="FONT-SIZE: 12pt"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN style="COLOR: blue; FONT-FAMILY: Arial">Aula Dr. Venancio
Deulofeu, Departamento de Química Orgánica</SPAN></B><SPAN
style="FONT-SIZE: 12pt"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN lang=ES-AR
style="COLOR: blue; FONT-FAMILY: Arial; mso-ansi-language: ES-AR">Ciudad
Universitaria, Pab. II, Piso 3</SPAN></B><SPAN lang=ES-AR
style="FONT-SIZE: 12pt; mso-ansi-language: ES-AR"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN lang=ES-AR
style="COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><o:p> </o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN lang=ES-AR
style="FONT-SIZE: 20pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR">Bqo.
Juan Bisceglia<o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN lang=ES-AR
style="COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><o:p> </o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm -33.75pt 0pt 0cm; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-fareast-font-family: 'MS Gothic'; mso-fareast-language: JA; mso-bidi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.0pt">Departamento
de Química Orgánica, Facultad de Ciencias Exactas y
Naturales,<o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-fareast-font-family: 'MS Gothic'; mso-fareast-language: JA; mso-bidi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.0pt">Universidad
de Buenos Aires.</SPAN></B><SPAN lang=ES-AR
style="FONT-SIZE: 14pt; mso-ansi-language: ES-AR"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><SPAN lang=ES-AR
style="FONT-SIZE: 8pt; mso-ansi-language: ES-AR"><o:p><FONT
face="Times New Roman"> </FONT></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 18pt"><FONT face="Times New Roman">Apoptolidina y Apoptosis:
Control Químico de <?xml:namespace prefix = st1 ns =
"urn:schemas-microsoft-com:office:smarttags" /><st1:PersonName w:st="on"
ProductID="la Muerte Celular">la Muerte
Celular</st1:PersonName><o:p></o:p></FONT></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 8pt"><o:p><FONT
face="Times New Roman"> </FONT></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify"><SPAN
style="FONT-SIZE: 12pt"><FONT face="Times New Roman">La <I>apoptosis </I>(muerte
celular programada) resulta crucial para mantener la homeostasis en los
organismos pluricelulares. <o:p></o:p></FONT></SPAN></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify"><SPAN
style="FONT-SIZE: 12pt"><FONT face="Times New Roman">Su correcto funcionamiento
es indispensable para la morfogénesis y para la eliminación de células
superfluas; mientras que su alteración está íntimamente relacionada con la
aparición de enfermedades degenerativas (Alzheimer) o proliferativas
(cáncer).</FONT><A title="" style="mso-footnote-id: ftn1"
href="mhtml:mid://00000010/#_ftn1" name=_ftnref1><SPAN
class=MsoFootnoteReference><SPAN style="mso-special-character: footnote"><SPAN
class=MsoFootnoteReference><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: ES; mso-fareast-language: ES; mso-bidi-language: AR-SA">[1]</SPAN></SPAN></SPAN></SPAN></A><FONT
face="Times New Roman"> </FONT></SPAN><B
style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 18pt"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify"><SPAN
style="FONT-SIZE: 12pt"><FONT face="Times New Roman">En los últimos años se ha
comprobado que la mayor parte de las terapias anticancerosas vigentes surten
efecto precisamente por su capacidad de disminuir la resistencia a la apoptosis
de las células tumorales.</FONT><A title="" style="mso-footnote-id: ftn2"
href="mhtml:mid://00000010/#_ftn2" name=_ftnref2><SPAN
class=MsoFootnoteReference><SPAN style="mso-special-character: footnote"><SPAN
class=MsoFootnoteReference><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: ES; mso-fareast-language: ES; mso-bidi-language: AR-SA">[2]</SPAN></SPAN></SPAN></SPAN></A><FONT
face="Times New Roman"> Esto implica que las sustancias capaces de modificar el
comportamiento celular ante la apoptosis resultan de importancia
médica.</FONT></SPAN><B style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 18pt"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify"><SPAN
style="FONT-SIZE: 12pt"><FONT face="Times New Roman">La <I>apoptolidina</I>,
aislada de <I>Nocardopsis sp.</I> en 1997, es un glicosil macrólido inicialmente
identificado por su capacidad de inducir apoptosis selectivamente en las células
gliales de rata transformadas con un oncogén de adenovirus.</FONT><A title=""
style="mso-footnote-id: ftn3" href="mhtml:mid://00000010/#_ftn3"
name=_ftnref3><SPAN class=MsoFootnoteReference><SPAN
style="mso-special-character: footnote"><SPAN class=MsoFootnoteReference><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: ES; mso-fareast-language: ES; mso-bidi-language: AR-SA">[3]</SPAN></SPAN></SPAN></SPAN></A><FONT
face="Times New Roman"> Un experimento llevado a cabo por el NCI demostró que se
encontraba dentro del 0,1% de los agentes citotóxicos más selectivos ensayados
(entre 37000 sustancias).</FONT></SPAN><B
style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 18pt"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify"><SPAN
style="FONT-SIZE: 12pt"><FONT face="Times New Roman">En el seminario se
presentará el fenómeno apoptótico junto con una breve descripción de su
bioquímica y se discutirán dos síntesis de la apoptolidina a partir de
precursores avanzados.<SUP>1,<A title="" style="mso-footnote-id: ftn4"
href="mhtml:mid://00000010/#_ftn4" name=_ftnref4><SPAN
class=MsoFootnoteReference><SPAN style="mso-special-character: footnote"><SPAN
class=MsoFootnoteReference><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: ES; mso-fareast-language: ES; mso-bidi-language: AR-SA">[4]</SPAN></SPAN></SPAN></SPAN></A>,<A
title="" style="mso-footnote-id: ftn5" href="mhtml:mid://00000010/#_ftn5"
name=_ftnref5><SPAN class=MsoFootnoteReference><SPAN
style="mso-special-character: footnote"><SPAN class=MsoFootnoteReference><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: ES; mso-fareast-language: ES; mso-bidi-language: AR-SA">[5]</SPAN></SPAN></SPAN></SPAN></A></SUP></FONT></SPAN><B
style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 18pt"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><o:p><FONT
face="Times New Roman"> </FONT></o:p></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><FONT face="Times New Roman"><IMG height=232
src="cid:000f01c7a474$bd86fb10$fc1f5c9d@Sergio" width=435 border=0
v:shapes="_x0000_i1025"></FONT></P>
<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center"
align=center><B><SPAN style="FONT-SIZE: 14pt"><FONT
face="Times New Roman">Apoptolidina</FONT></SPAN></B></P>
<DIV style="mso-element: footnote-list"><BR clear=all><FONT
face="Times New Roman">
<HR align=left width="33%" SIZE=1>
</FONT>
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face="Times New Roman"><SPAN style="mso-ansi-language: DE"> </SPAN><SPAN lang=DE
style="mso-ansi-language: DE; mso-bidi-language: OR">P. T. Daniel, U. Koert y J.
Schuppan.</SPAN><SPAN lang=DE
style="mso-ansi-language: DE; mso-bidi-font-family: AdvSCASI; mso-bidi-language: OR">
</SPAN><I><SPAN lang=EN-US
style="mso-ansi-language: EN-US; mso-bidi-font-family: AdvSCASI; mso-bidi-language: OR">Angew.
Chem. Int. Ed.</SPAN></I><SPAN lang=EN-US
style="mso-ansi-language: EN-US; mso-bidi-font-family: AdvSCASI; mso-bidi-language: OR">
</SPAN><SPAN lang=EN-US
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lang=EN-US
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</SPAN><B><SPAN lang=EN-US
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872 –893.</SPAN><SPAN lang=EN-US
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title="" style="mso-footnote-id: ftn2" href="mhtml:mid://00000010/#_ftnref2"
name=_ftn2><SPAN class=MsoFootnoteReference><SPAN
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lang=EN-US style="mso-ansi-language: EN-US"><FONT face="Times New Roman"> M.
Ridley. <I>Genome.</I> <st1:place w:st="on"><st1:PlaceName
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1999.<o:p></o:p></FONT></SPAN></P></DIV>
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face="Times New Roman"><SPAN style="mso-ansi-language: EN-US"> </SPAN><SPAN
lang=EN-US style="mso-ansi-language: EN-US; mso-bidi-language: OR">A. R.
Salomon, D. W. Voehringer, L. A. Herzenberg, C. Khosla.</SPAN><SPAN lang=EN-US
style="mso-ansi-language: EN-US; mso-bidi-font-family: AdvP4C4E51; mso-bidi-language: OR">
</SPAN><I><SPAN lang=EN-US
style="mso-ansi-language: EN-US; mso-bidi-language: OR">Chemistry & Biology,
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<P class=MsoFootnoteText style="MARGIN: 0cm 0cm 0pt"><SPAN lang=ES-AR><o:p><FONT
face="Times New Roman"> </FONT></o:p></SPAN></P></DIV></DIV></FONT></DIV></BODY></HTML>