<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Hola,</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Hoy jueves 26 a las 13 hs tenemos un invitado externo para el seminario. Aca va la informacion:</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><BR></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#0031EB">Dr. Tobias Walther </FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#0031EB">Dept. of Biochemistry and Biophysics, N316</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#0031EB">University of California, San Francisco</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#0031EB">San francisco, CA 94143</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#0031EB">USA</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><FONT class="Apple-style-span" color="#0032EB"><BR></FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><FONT class="Apple-style-span" color="#0032EB"><BR></FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#0032EB"><B>Title: EIsosomes show the door: The discovery of static sites of endocytosis in yeast.</B></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Breve descripcion del trabajo:</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">The plasma membrane is a highly dynamic structure that is constantly remodeled by membrane transport events. Exocytosis mediates the delivery of lipids and proteins to the surface for cell growth, communication, and secretion of cargos. Endocytosis balances the delivery of membrane, is essential for the uptake of nutrients and pathogens, and mediates the regulation of receptors and transporters. To maintain a functional plasma membrane of appropriate composition at homeostasis, the cell constantly balances endocytosis and exocytosis to compensate for changes in the environment or growth phase.</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">We recently discovered large protein assemblies, which we call ³eisosomes², that lay underneath the plasma membrane in the yeast S. cerevisiae. Our experiments indicate that eisosomes function as static ³endocytic portals² that determine when and where endocytic events initiate. The discovery of eisosomes raises many intriguing questions, which I intend to address in my group. How do eisosomes affect and regulate endocytosis? How are they targeted to specific sites at the plasma membrane and assembled there?</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Tobi esta buscando estudiantes de doctorado y/o postdoctorado. Abajo les pasteo 2 avisos al respecto. Los interesados, si quieren, pueden hablar con el directamente mañana.</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><BR class="khtml-block-placeholder"></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Los ministros </DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Alejandro Colman Lerner</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Fernando Marengo</DIV></BODY></HTML>