<html>
Les envío información de un seminario, podrían difundirlo en su
Instituto, Facultad, etc., Están todos cordialmente invitados.<br>
<br>
Agradeceré confirmación<br>
<br>
Saludos<br>
<br>
<br>
<br>
<font face="Verdana" size=2 color="#FF0000"><b>SEMINARIO DEL IFIBYNE
<br>
VIERNES 29 de SEPTIEMBRE <br>
16.30 HRS<br>
<br>
</b></font><font face="Verdana" size=2>Facultad de Ciencias Exactas y
Naturales Pabellon II<br>
AULA A CONFIRMAR<br>
<br>
<br>
</font><b>Regulator of G protein signaling (RGS2) family determines
short-term synaptic plasticity in Hippocampal Neurons<br>
<br>
Stephan Herlitze PhD.<br>
<br>
<br>
</b><font face="Verdana" size=1>Department of Neurosciences, Case Western
Reserve University, School of Medicine, Room E 604, 10900 Euclid Avenue,
Cleveland, Ohio 44106<br>
<br>
<br>
</font><font face="Verdana">My lab is interested in understanding ion
channel function and system modulation in animal physiology and behavior.
Our research is centered on the characterization of voltage gated
Ca</font><font face="Verdana" size=1><sup>2+</sup></font><font face="Verdana">
channels and their modulatory proteins in cerebellum and hindbrain. We
will apply patch clamp measurements in cultured cells and slice
preparations, virus mediated infection methods (Sindbis virus), imaging
techniques (two photon microscopy, TIRF, FLIM, FRET, FRAP, BiFC) and
mouse genetics (transgene expression and homologous recombination) to
investigate the following topics: <br>
<br>
<br>
<i>1.<x-tab> </x-tab>Defining the role
of P/Q-type
Ca</font><font face="Verdana" size=1><sup>2+</sup></font><font face="Verdana">
channels domains for subcellular targeting, function and animal
behavior.<br>
2.<x-tab> </x-tab>Defining the role of
G protein modulation and neuronal activity of the serotonergic
transmitter system for animal physiology (blood pressure regulation) and
behavior (anxiety and depression).<br>
<br>
</i></font><b>RECENT PAPERS<br>
<br>
</b>Han J, Mark MD, Li X, Xie M, Waka S, Rettig J, Herlitze
S<font color="#0033CC"><u>.<br>
</u></font>RGS2 Determines Short-Term Synaptic Plasticity in Hippocampal
Neurons by Regulating G(i/o)- Mediated Inhibition of Presynaptic Ca(2+)
Channels. <b>Neuron. 2006 Sep 7;51(5):575-86.</b> <br>
<br>
Li X, Gutierrez DV, Hanson MG, Han J, Mark MD, Chiel H, Hegemann P,
Landmesser LT, Herlitze S.<br>
Fast noninvasive activation and inhibition of neural and network activity
by vertebrate rhodopsin and green algae channelrhodopsin.<br>
<b>Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17816-21</b> <br>
<br>
<br>
<br>
</html>