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<DIV align=center><B><FONT face=Arial color=blue size=5><SPAN
style="FONT-WEIGHT: bold; FONT-SIZE: 16pt; COLOR: blue; FONT-FAMILY: Arial">
SEMINARIO DE QUÍMICA ORGÁNICA 2006</SPAN></FONT></B></DIV>
<P class=MsoNormal style="MARGIN-LEFT: 36pt; TEXT-ALIGN: center"
align=center><B><U><FONT face=Arial color=blue size=3><SPAN
style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; COLOR: blue; FONT-FAMILY: Arial"><A
href="http://www.qo.fcen.uba.ar/Cursos/semin.htm"><FONT color=red size=2><SPAN
style="FONT-SIZE: 10pt; COLOR: red">http://www.qo.fcen.uba.ar/Cursos/semin.htm</SPAN></FONT></A></SPAN></FONT></U></B></P>
<P class=MsoNormal style="MARGIN-LEFT: 36pt; TEXT-ALIGN: center"
align=center><FONT face="Times New Roman" color=blue size=3><SPAN
style="FONT-SIZE: 12pt; COLOR: blue"></SPAN></FONT> </P>
<P class=MsoNormal style="MARGIN-LEFT: 36pt; TEXT-ALIGN: center"
align=center><B><FONT face=Arial color=blue size=2><SPAN
style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; COLOR: blue; FONT-FAMILY: Arial">Miércoles 10
de Mayo, 13 hs</SPAN></FONT></B></P>
<P class=MsoNormal style="MARGIN-LEFT: 36pt; TEXT-ALIGN: center"
align=center><B><FONT face=Arial color=blue size=2><SPAN lang=PT-BR
style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; COLOR: blue; FONT-FAMILY: Arial">Aula
Dr. Venancio Deulofeu</SPAN></FONT></B></P>
<P class=MsoNormal style="MARGIN-LEFT: 36pt; TEXT-ALIGN: center"
align=center><B><FONT face=Arial color=blue size=2><SPAN lang=PT-BR
style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; COLOR: blue; FONT-FAMILY: Arial">Departamento
de Química Orgánica</SPAN></FONT></B></P>
<P class=MsoNormal style="MARGIN-LEFT: 36pt; TEXT-ALIGN: center"
align=center><B><FONT face=Arial color=blue size=2><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; COLOR: blue; FONT-FAMILY: Arial">Ciudad
Universitaria, Pab. II, Piso 3</SPAN></FONT></B></P>
<P class=MsoNormal style="MARGIN-LEFT: 36pt"><FONT face="Times New Roman"
color=blue><SPAN
style="FONT-SIZE: 12pt; COLOR: blue"></SPAN></FONT> </P><FONT
face="Times New Roman" color=blue size=3><SPAN
style="FONT-SIZE: 12pt; COLOR: blue"><SPAN lang=ES-AR
style="FONT-SIZE: 20pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><SPAN
style="FONT-SIZE: 11pt; FONT-FAMILY: Arial; mso-ansi-language: ES; mso-fareast-font-family: 'Times New Roman'; mso-fareast-language: ES; mso-bidi-language: AR-SA"><FONT
size=4><SPAN lang=ES-AR
style="FONT-SIZE: 20pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><FONT
size=4>
<P class=MsoNormal
style="MARGIN: 0pt; TEXT-ALIGN: center; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto"
align=center><SPAN lang=ES-AR
style="FONT-SIZE: 20pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><STRONG>Dr.
Fabio Doctorovich<o:p></o:p></STRONG></SPAN></P>
<P class=MsoNormal style="MARGIN: 0pt; TEXT-ALIGN: center" align=center><SPAN
lang=ES-AR
style="COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><o:p><FONT
size=2><STRONG> </STRONG></FONT></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0pt; TEXT-ALIGN: center" align=center><SPAN
lang=ES-AR
style="FONT-SIZE: 14pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: ES-AR"><STRONG>Dpto.
de Química Inorgánica, Analítica y Química Física / INQUIMAE, FCEyN, Universidad
de Buenos Aires<o:p></o:p></STRONG></SPAN></P>
<P class=MsoNormal style="MARGIN: 0pt; TEXT-ALIGN: center" align=center><SPAN
lang=ES-AR
style="FONT-SIZE: 14pt; mso-ansi-language: ES-AR"><o:p></o:p></SPAN> </P>
<P class=MsoNormal style="MARGIN: 0pt; TEXT-ALIGN: center" align=center><SPAN
lang=ES-AR
style="FONT-SIZE: 14pt; mso-ansi-language: ES-AR"><o:p> </o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 0pt; TEXT-ALIGN: center" align=center><SPAN
style="FONT-SIZE: 16pt; COLOR: black; FONT-FAMILY: Arial"><STRONG>Haciendo
Química Orgánica con Compuestos Inorgánicos… y
Viceversa<o:p></o:p></STRONG></SPAN></P>
<P class=MsoNormal style="MARGIN: 0pt; TEXT-ALIGN: center" align=left><SPAN
style="FONT-SIZE: 16pt; COLOR: black; FONT-FAMILY: Arial"><o:p><STRONG> </STRONG></o:p></SPAN></P>
<P class=MsoBodyText2 style="MARGIN: 6pt -44.1pt 0pt -36pt; LINE-HEIGHT: 150%"
align=left><SPAN style="FONT-SIZE: 12pt; LINE-HEIGHT: 150%"><SPAN
style="mso-tab-count: 1"></SPAN></SPAN><SPAN
style="FONT-SIZE: 12pt; COLOR: black; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-fareast-language: ES">En
la </P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: 150%"><SPAN
style="FONT-SIZE: 12pt; LINE-HEIGHT: 150%"><SPAN
style="mso-tab-count: 1">
</SPAN></SPAN><SPAN
style="FONT-SIZE: 12pt; COLOR: black; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-fareast-language: ES">En
la presente charla les mostraré algunos ejemplos del trabajo que hemos estado
haciendo en los últimos tiempos, tratando de centrarme en aquellos que presentan
más interés para la Química Orgánica.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: 150%"><SPAN
style="FONT-SIZE: 12pt; COLOR: black; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-fareast-language: ES"><o:p> </o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: 150%"><SPAN
style="FONT-SIZE: 12pt; COLOR: black; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-fareast-language: ES">-<B
style="mso-bidi-font-weight: normal">Donores de NO</B>: presentaré a la
nitrosomelatonina como un donor de óxido nítrico, y describiré las reacciones de
transnitrosación entre nitrosotioles y tioles.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: 150%"><SPAN
style="FONT-SIZE: 12pt; COLOR: black; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-fareast-language: ES">-<B
style="mso-bidi-font-weight: normal">Reducción de alquenos</B>: el diaceno
(HN=NH) estabilizado por coordinación al catalizador [Fe(CN)5(H2O)]3-, es un
reactivo versátil, limpio y eficiente para la reducción de alquenos en medio
acuoso u orgánico.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: 150%"><SPAN
style="FONT-SIZE: 12pt; COLOR: black; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-fareast-language: ES">-<B
style="mso-bidi-font-weight: normal">Estabilización de especies reactivas:</B>
las extremadamente reactivas nitrosaminas primarias, los nitrosotioles, y los
C-nitrosocompuestos, se obtienen fácilmente como compuestos estables por
reacción de [IrCl5(NO)]– con aminas primarias, tioles y alquenos
respectivamente. <o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: 150%"><SPAN
style="FONT-SIZE: 12pt; COLOR: black; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-fareast-language: ES"><o:p> </o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: 150%"><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; COLOR: black; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-fareast-language: ES">Referencias<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: normal"><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-fareast-language: ES">Formation
of a Coordinated C-Nitroso by Reaction of K[IrCl5NO] with Dicyclopentadiene.
Escola, N.; Leitus, G.; Doctorovich, F. Organometallics,
aceptado.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: normal"><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-fareast-language: ES">A
Surprisingly Stable S-Nitrosothiol Complex, Perissinotti, L.; Estrin D.; Leitus,
G.; Doctorovich, F. J. Am. Chem. Soc. 2006, 128,
2512-2513.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: normal"><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-fareast-language: ES">Formation
of Coordinated Nitrosamines by Reaction of K[IrCl5NO] with Primary Amines
Doctorovich, F.; Di Salvo, F.; Escola, N.; Trápani, C.; Shimon, L.
Organometallics, 2005, 24, 4707-4709.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: normal"><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-fareast-language: ES">Mechanisms
of NO release by N1-Nitrosomelatonin: Nucleophilic Attack versus Reducing
Pathways De Biase, P. M.; Turjanski, A. G.; Estrin, D. A.; Doctorovich, F. J.
Org. Chem. 2005, 70, 5790-5798.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: normal"><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-fareast-language: ES">Transnitrosation
of Nitrosothiols: Characterization of an Elusive Intermediate, Perissinotti, L.;
Turjanski, A.; Estrin, D.; Doctorovich, F. J. Am. Chem. Soc. 2005, 127,
486-487.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: normal"><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-fareast-language: ES">Metal-Catalyzed
Anaerobic Disproportionation of Hydroxylamine. Role of Diazene and Nitroxyl
Intermediates in the Formation of N2, N2O, NO+ and NH3, Alluisetti, G. E.;
Almaraz, A. E.; Amorebieta, V. T.; Doctorovich F.; Olabe, J. A. J. Am.
</SPAN><SPAN
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-fareast-language: ES">Chem.
Soc. 2004, 126, 13432-13442.<o:p></o:p></SPAN></P>
<P class=MsoBodyText2
style="MARGIN: 6pt -17.1pt 0pt 0pt; LINE-HEIGHT: normal"><SPAN lang=EN-GB
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB; mso-fareast-language: ES">Scavenging
of NO by Melatonin, Turjanski, A.; Leonik, F.; Estrin, D.; Rosenstein, R. E. y
Doctorovich, F. J. Am. </SPAN><SPAN
style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial; mso-fareast-language: ES">Chem.
Soc., 2000, 122, 10468.<o:p></o:p></SPAN></P>
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