[Todos] Seminarios conjuntos IFIBYNE-DFBMC- Marcelo Rubinstein- 30/06/11- 13 Hs.- RECORDATORIO

[Paula Felman]

Jueves 30 de junio 13 Hs. en el aula de seminarios.

Marcelo Rubinstein

Titulo: Bases neurogenéticas de conductas 
apetitivas y adictivas: autoreceptores y control 
de la neurotransmisión dopaminérgica

Resumen: Dopamine (DA) D2 receptors expressed in 
DA neurons (D2 autoreceptors) exert a negative 
feedback regulation that reduces DA neuron 
firing, DA synthesis and release. Since D2 
receptors are mostly expressed in postsynaptic 
neurons, pharmacological and genetic approaches 
have been unable to definitively address the in 
vivo contribution of D2 autoreceptors to 
DA-mediated behaviors. During this talk I will 
report that midbrain DA neurons from mutant mice 
deficient in D2 autoreceptors (autoDrd2–/–) lack 
DA-mediated somatodendritic synaptic responses 
and inhibition of DA release. AutoDrd2–/– mice 
display elevated DA synthesis and release, 
hyperlocomotion and supersensitivity to the 
psychomotor effects of cocaine. AutoDrd2–/– mice 
also exhibit increased place preference for 
cocaine and enhanced motivation for food reward. 
This study highlights the importance of D2 
autoreceptors in motor function, food seeking 
behavior and sensitivity to the locomotor and 
rewarding properties of cocaine and suggests that 
individual variation in D2 autoreceptor 
expression could influence personality traits and 
be involved in drug addiction, impulsivity and schizophrenia.

Host: Alejandro Colman Lerner
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