[Todos] Seminarios conjuntos IFIBYNE-DFBMC- Lucas Pozzo-Miller- Viernes 15 de Julio 13 Hs.

[Daniela De Luca]

>Viernes  15 de Julio 13 Hs. en el aula de seminarios.
>
>Lucas Pozzo-Miller, Ph.D. Professor of Neurobiology.  The University
>of Alabama at Birmingham
>
>Titulo: "BDNF Actions on both Sides of Synapses: TRPC Channels, MeCP2
>and the Cellular Neuropathology of Rett Syndrome"
>
>Resumen: Dysfunctions of neuronal and network excitability have
>emerged as common features in disorders associated with intellectual
>disabilities, autism and seizure activity, all common clinical
>manifestations of Rett syndrome (RTT), a neurodevelopmental disorder
>caused by loss-of-function mutations in the transcriptional regulator
>MeCP2. I will discuss the consequences of Mecp2 mutation on
>hippocampal network excitability, as well as synapse structure and
>function evaluated with a combination of imaging and
>electrophysiological approaches in acute slices. Imaging the
>amplitude and spatiotemporal spread of neuronal depolarizations with
>voltage-sensitive dyes (VSD) revealed that the CA1 and CA3 regions of
>hippocampal slices from symptomatic male Mecp2 mutant mice are highly
>hyperexcitable. However, only the density of docked synaptic vesicles
>and the rate of release from the readily releasable pool are impaired
>in Mecp2 mutant mice, while synapse density and morphology are
>unaffected. The differences in network excitability were not observed
>in surgically isolated CA1 mini-slices, and blockade of GABAergic
>inhibition enhanced VSD signals to the same extent in Mecp2 mutant
>and wildtype mice, suggesting that network excitability originates in
>area CA3. Indeed, extracellular multi-unit recordings revealed a
>higher level of spontaneous firing of CA3 pyramidal neurons in slices
>from symptomatic Mecp2 mutant mice. The present results suggest that
>hyperactive CA3 pyramidal neurons contribute to hippocampal
>dysfunction and possibly to limbic seizures observed in Mecp2 mutant
>mice and RTT individuals.
>
>
>Host: Veronica de la Fuente
>
>
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>271.1.1/3758 - Fecha de la versión: 07/11/11 03:35:00