[Todos] Coloquios del Departamento de Física

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                            COLOQUIOS DEL DEPARTAMENTO DE FÍSICA FCEyN - UBA

                                       http://coloquios.df.uba.ar/

                                          Charla, café y galletitas
                                     En el Aula Federman, 1er piso Pabellón I,
                                             Ciudad Universitaria


                                        Jueves 2 de septiembre, 14hs,


                      Functional plasma polymer films at the nanoscale
                                    for biomaterial applications


                                           Krasimir Vasilev

                    Mawson Institute and School for Advanced Manufacturing
                                  University of South Australia



Functional coatings presenting a variety of functional surface groups  
(e.g. amine, carboxyl, epoxy, aldehyde, etc) can be readily prepared  
by plasma polymerisation in an easy one step process. Applications of  
such films span over a range of fields from modification of  
biomaterials to protective coatings.

In my talk I will present recent developments from our group on  
various biomaterial coatings prepared by plasma polymerisation which  
include chemical and biomolecular gradients, antibacterial coatings  
and drug release platforms.

Surface gradients are important tools for studying and guiding  
cellular responses such as migration, adhesion, differentiation, etc.  
We are particularly interested in density gradients of nanoparticles  
which we aim to use as a tool to study how the magnitude and spacing  
of the nanoscale surface features affect cell behaviour.

In the second part of my talk I will present our recent research on  
development of antibacterial coatings. Varying parameters such as time  
of reduction, time of silver loading and thickness of the plasma  
polymer film gave us a versatile tool for controlling the amount of  
silver nanoparticles loaded in the films. Bacterial tests showed  
excellent antibacterial properties against both gram positive and gram  
negative bacteria.

In the last part of my talk I will present methods for fabrication of  
drug delivery platforms for controlled release.  Control of the  
release rate of the drug is exercised via a plasma polymer films which  
covers the drug particles, and the thickness of the plasma polymer  
film determines the release kinetics.