[Todos] Seminarios conjuntos DFBMC-IFIByNE- Dr. Genís Parra Farré (miércoles 18 de marzo)

[Paula Felman]

Seminario miércoles 18 de marzo, 13 hs. Aula de seminarios del LFBM

DFBMC e IFIBYNE: Dr. Genís Parra Farré

Genís Parra Farré
Genome Center. University of California Davis.

"Intron Mediated Enhancement of gene expression"

Shortly after introns were discovered, it was noted that several genes were 
expressed very poorly when their introns were removed. Introns that elevate 
mRNA accumulation have been found in a wide range of eukaryotes. This 
phenomenon is called intron mediated enhancement (IME). The mechanism of 
IME is largely unknown but it is not
due to traditional transcriptional enhancers embedded in introns. However, 
not all introns affect gene expression, and direct testing is currently the 
only way to identify stimulatory introns. Our genome-wide analysis in 
A.thaliana revealed that promoter-proximal introns as a group are 
compositionally distinct from distal introns and that the degree to which 
an individual intron matches the promoter-proximal intron profile is a 
strong predictor of its ability to enhance expression. We extended this 
analysis to some vertebrate species to find out interesting similarities.

Host: Alberto Kornblihtt

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