[Todos] Seminarios conjuntos DFBMC-IFIByNE- Rafael Pagani

[Paula Felman]

Seminario jueves 12 de marzo, 13 hs. Aula de seminarios del LFBM

Rafael Pagani



Gain-of-Function Mutations Causing Noonan Syndrome Modulate the Inter-trial 
Interval required for Long-term Memory Induction in Drosophila


SUMMARY
Noonan syndrome (NS) is a genetic disorder comprising a range of 
developmental and cognitive abnormalities. The major cause is 
gain-of-function (GOF) mutations in PTPN11, which encodes the tyrosine 
phosphatase SHP-2. To gain insights into these cognitive alterations, we 
used transgenic Drosophila NS models inducibly expressing the fly SHP-2 
orthologue, corkscrew (CSW). Our studies revealed that GOF CSW impairs 
long-term memory (LTM) formation even when acutely expressed in adulthood. 
A universal property of LTM induction is the requirement for repeated 
training sessions spaced over time. The molecular basis of this spacing 
effect is completely unknown. We demonstrated that wild-type CSW 
overexpression dramatically shortened the interval between training 
sessions required for LTM induction. Conversely, the LTM formation defect 
in the NS fly models could be rescued by increasing the inter-trial 
interval. Thus, we provide the first evidence that the spacing effect has a 
molecular base and CSW/SHP-2 is key in its regulation.

Host: Alejandro Colman Lerner
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