[Todos] Ph.D. Studentship available - starting Oct 2007 (fwd)

[Horacio Grinberg]

Hola a todos:
 	Por si alguien esta interesado reenvio el presente mensaje.
Saludos,
Horacio Grinberg

---------- Forwarded message ----------
Date: Thu, 7 Jun 2007 12:30:31 +0100
From: "Barter, Laura M C" <l.barter en IMPERIAL.AC.UK>
To: MOLECULAR-DYNAMICS-NEWS en JISCMAIL.AC.UK
Subject: Ph.D. Studentship available - starting Oct 2007

Dear All,
I would be most grateful if you could circulate this email within your department and bring the following PhD studentship to the attention of any prospective students who you feel may be interested in this project.
Kind regards,
Laura Barter
 	Ph.D. Studentship available starting Oct 2007
*	We are currently inviting applications for a four year Ph.D. studentship starting in October 2007.
*	The project title is "Reactive Intermediates in Membrane Proteins Studied by 2D-IR Spectroscopy" (Please see below for details about the project).
*	The project would be suited to someone with an interest in optics, lasers and spectroscopy who is interested in solving problems at the life science/physical science interface.
*	This is a Chemical Biology Centre (CBC) studentship. The Chemical Biology Centre is a joint venture of Imperial College London, The Institute of Cancer Research and the London Research Institute of Cancer Research UK.
*	The CBC aims to provide physical science graduate students with cross departmental, cross institutional, multidisciplinary training towards careers at the physical science / life science interface.
*	PhD students will qualify for a Masters in Research (MRes) in Chemical Biology after their first year, which is followed by three more years of funded research leading to a PhD. (The stipend ~£14,400).
*	Further details and the online application form can be found at <http://www.chemicalbiology.ac.uk/st_2dir.html>
*
If you are interested in this position or would like to have more information please do not hesitate to contact Dr Laura Barter (l.barter en imperial.ac.uk) or Prof David Klug (d.klug en imperial.ac.uk).

For more general enquiries about the CBC please see <http://www.chemicalbiology.ac.uk/> or contact cbcadmin en imperial.ac.uk



Reactive Intermediates in Membrane Proteins Studied by 2DIR Spectroscopy

This project employs a novel instrument capable of probing changes in molecular structure. It is a 2 dimensional-IR technique, where 2 laser beams excite 2 different vibrations in a complex and the degree of coupling between the molecular vibrations can be determined, by probing the sample with a third "readout" laser beam. As coupling is very sensitive to the chemical structure of a system, information obtained from the experiment allows the distance between the vibrations, and the strain of the molecular bonds between them, to be determined. If this technique is able to determine large protein structures the implications would be enormous. For example watching how structures change during an enzyme reaction would allow structure function relationships to be developed and could impact on future rational design in enzymology.

This project does not aim to solve a whole protein structure, but will consider two biological systems, whose structures are known with reasonable resolution. The technique will be used to home-in on the active site and observe structural changes that occur during the chemical reactions to probe the mechanism.
This technique has great potential as a tool for exploring enzymatic mechanisms and the changes that occur in proteins during catalytic cycles. While structural data from techniques such as X-ray crystallography provide information on the location of atoms and molecules, it cannot provide information on the timescale of most enzymatic reactions. 2D-IR spectroscopic methods have the potential to do just this.






Dr Laura M. C. Barter
Biological & Biophysical Chemistry Section
Room 249b Dept. of Chemistry,
South Kensington Campus,
Exhibition Road,
Imperial College London,
SW7 2AZ
Tel: 0207 594 1885
    or 0207 594 5807
Fax: 0207 594 5880
http://www3.imperial.ac.uk/people/l.barter


To join or leave the molecular-dynamics-news email list, go to:
http://www.jiscmail.ac.uk/lists/molecular-dynamics-news.html