[Todos] PROXIMO SEMINARIO

[Fernando V. Molina]

Viernes 24 de agosto - 13 hs

Aula de Seminarios INQUIMAE-DQIAQF (3º piso Pab. II)


Prof. Peter Wollyness
Centre for Theoretical Biological Physics
University of California at San Diego

"Energy Landscape Theory of Proteins"


Abstract:
   Twenty-five years ago, how proteins folded 
into organized  structures on the basis of their 
sequence was a great mystery. By  characterizing 
the energy landscapes of proteins with tools from 
the statistical mechanics of disordered systems like spin
glasses, a “new  view” of the folding process 
became possible. Energy landscape 
theory  provided an incentive to pursue heroic 
new experiments and to carry out difficult 
computer simulations addressing protein folding mechanisms.
   Many aspects of folding kinetics revealed by 
these studies can be quantitatively understood 
using the simple idea that the topography  of the 
energy landscape is that of a “rugged funnel”.
   Energy landscape theory provided a 
quantitative means of characterizing which amino 
acid sequences can rapidly fold.   Algorithms 
based on energy landscape theory have been used 
to successfully design novel sequences that fold 
to a given structure in the laboratory.
   Energy landscape ideas have begun to transform 
the prediction of protein structure from sequence 
data from being an art to being a science. The 
success of energy landscape- based algorithms in 
predicting protein structure from sequence will be
highlighted. While there is still much to learn 
about folding mechanisms and much work to do 
achieving universally reliable structure 
prediction, many parts of what used to be called 
“the protein folding problem” can now be considered solved.



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