[Todos] Recordatorio - Seminario del IFIBYNE

[Dana Felman]

Les envio el recordatorio del Seminario de mañana, confirmando el horario y 
el aula. EStán todos cordialmente invitados, habrá café y cosas ricas para 
merendar.

Favor de difundir.

Los esperamos


SEMINARIO DEL IFIBYNE
VIERNES 29 de SEPTIEMBRE
16.30 HRS - AULA 7

Facultad de Ciencias Exactas y Naturales Pabellon II
AULA A CONFIRMAR


Regulator of G protein signaling (RGS2) family determines short-term 
synaptic plasticity in Hippocampal Neurons

Stephan Herlitze PhD.


Department of Neurosciences, Case Western Reserve University, School of 
Medicine, Room E 604, 10900 Euclid Avenue, Cleveland, Ohio 44106


My lab is interested in understanding ion channel function and system 
modulation in animal physiology and behavior. Our research is centered on 
the characterization of voltage gated Ca2+ channels and their modulatory 
proteins in cerebellum and hindbrain. We will apply patch clamp 
measurements in cultured cells and slice preparations, virus mediated 
infection methods (Sindbis virus), imaging techniques (two photon 
microscopy, TIRF, FLIM, FRET, FRAP, BiFC) and mouse genetics (transgene 
expression and homologous recombination) to investigate the following topics:


1.      Defining the role of P/Q-type Ca2+ channels domains for subcellular 
targeting, function and animal behavior.
2.      Defining the role of G protein modulation and neuronal activity of 
the serotonergic transmitter system for animal physiology (blood pressure 
regulation) and behavior (anxiety and depression).

RECENT PAPERS

Han J, Mark MD, Li X, Xie M, Waka S, Rettig J, Herlitze S.
RGS2 Determines Short-Term Synaptic Plasticity in Hippocampal Neurons by 
Regulating G(i/o)- Mediated Inhibition of Presynaptic Ca(2+) 
Channels.  Neuron. 2006 Sep 7;51(5):575-86.

Li X, Gutierrez DV, Hanson MG, Han J, Mark MD, Chiel H, Hegemann P, 
Landmesser LT, Herlitze S.
Fast noninvasive activation and inhibition of neural and network activity 
by vertebrate rhodopsin and green algae channelrhodopsin.
Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17816-21



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